生长抑素受体2蛋白表达与肺神经内分泌肿瘤临床病理特征及预后关系分析  

Relationship between somatostatin receptor 2 protein expression and clinicopathological characteristics and prognosis of pulmonary neuroendocrine neoplasms

作　　者：刘家亮 李云婷 蔡晓珊 张云香[1,3] LIU Jia-liang;LI Yun-ting;CAI Xiao-shan;ZHANG Yun-xiang(Weifang People's Hospital,Shandong Second Medical University,Weifang 261000,China;Weifang Second People's Hospital,Weifang 261000,China;Department of Molecular Pathology,Qingdao Central Hsopital,University of Health and Rehabilitation Sciences,Qingdao 266000,China)

机构地区：[1]山东第二医科大学第一附属医院(潍坊市人民医院)精准病理诊断中心,山东潍坊261000 [2]潍坊市第二人民医院病理科,山东潍坊261000 [3]康复大学青岛中心医院分子病理科,青岛266000

出　　处：《诊断病理学杂志》2025年第2期126-132,共7页Chinese Journal of Diagnostic Pathology

基　　金：山东省自然科学基金面上项目(ZR2023MH064);山东省医药卫生科技项目(重点项目,202302061370);潍坊市科技发展计划项目(2022YX001)。

摘　　要：目的探讨生长抑素受体2(SSTR2)与肺神经内分泌肿瘤(NENs)临床病理特征及预后的关系。方法免疫组化检测120例经手术切除的肺NENs中SSTR2的表达情况,随访患者生存情况,分析SSTR2与肺NENs临床病理特征及预后关系。结果SSTR2表达与肺NENs的肿瘤类型、Ki-67指数、肿瘤大小、淋巴结转移、TNM分期等临床病理特征相关(P<0.05)。肺NENs级别与SSTR2表达强度呈负相关(P<0.05)。Kaplan-Meier生存分析显示:SSTR2表达、肿瘤大小、淋巴结转移、TNM分期等因素与肺NENs患者总生存期(OS)相关(P<0.05)。多因素Cox回归分析显示:SSTR2、肿瘤大小、TNM分期是影响肺NENs患者死亡的独立风险因素。结论SSTR2表达与肺NENs患者临床病理特征关系密切,且可作为评估肺NENs患者预后的指标。Objective To investigate the relationship between somatostatin receptor 2(SSTR2)and the clinicopathological features and prognosis of pulmonary neuroendocrine neoplasms(NENs).Methods Immunohistochemistry was used to detect the expression of SSTR2 in 120 cases of surgically resected pulmonary NENs,and the survival of the patients was followed up,and the clinicopathological features and prognostic relationship between SSTR2 and pulmonary NENs were analyzed.Results SSTR2 expression was correlated with the clinicopathological features of pulmonary NENs,such as tumor type,Ki-67 index,tumor size,lymph node metastasis,and TNM stage(P<0.05).The level of pulmonary NENs was negatively correlated with the intensity of SSTR2 expression(P<0.05).Univariate Kaplan-Meier survival analysis showed that SSTR2 expression,tumor size,lymph node metastasis,TNM stage and other factors were associated with overall survival(OS)in patients with pulmonary NENs(P<0.05).Multivariate Cox regression analysis showed that SSTR2,tumor size,and TNM stage were independent risk factors for mortality in patients with pulmonary NENs.Conclusion SSTR2 expression is closely related to the clinicopathological characteristics of patients with pulmonary NENs,and it can be used as an indicator to evaluate the prognosis of patients with pulmonary NENs.

关 键 词：肺 神经内分泌肿瘤 SSTR2 临床病理特征 预后 

分 类 号：R734.2[医药卫生—肿瘤]