TSR和S-TLII在海南鼻咽癌患者的分布及对预后的影响  

Prognostic impact of tumor-stroma ratio and stromal lymphocyte infiltrating intensity on patients with nasopharyngeal carcinoma

作　　者：孙祺敏 毕悦渤 牛海艳 郑艺菲 吴文婷 陆云龙 杜乐 杨文君[1,2] SUN Qi-min;BI Yue-bo;NIU Hai-yan;ZHENG Yi-fei;WU Wen-ting;LU Yun-long;DU Le;YANG Wen-jun(Key Laboratory of Tropical Translational Medicine of Ministry of Education,School of Basic Medical Sciences and Life Sciences,Hainan Medical University,Haikou 571199,China;Department of Pathology,the First Affiliated Hospital,Hainan Medical University,Haikou 570102,China)

机构地区：[1]海南医科大学基础医学与生命科学学院热带转化医学教育部重点实验室,海口571199 [2]海南医科大学第一附属医院病理科,海口570102

出　　处：《诊断病理学杂志》2025年第2期182-187,共6页Chinese Journal of Diagnostic Pathology

基　　金：海南省科技厅重点研发项目(ZDYF2024SHFZ087)。

摘　　要：目的探讨肿瘤间质比(TSR)和间质淋巴细胞浸润强度(S-TLII)在107例海南鼻咽癌(NPC)患者中的分布及对预后的影响。方法选择2016年1月至2019年12月期间于海南医科大学第一附属医院住院治疗的131例海南NPC患者筛选出107例,收集人口学、临床病理、及预后资料,以50%的TSR为界限,将NPC患者分为低TSR组(≤50%)和高TSR组(>50%)。分析TSR、S-TLII与NPC患者的无病生存期(DFS)及总生存期(OS)的关系。结果107例NPC患者1年、3年、5年OS率和DFS率分别为91.5%、76.4%、70.5%和86.9%、68.2%、62.6%。NPC低TSR和高TSR患者分别为42例(39.3%)和65例(60.7%),低TSR组的OS(45.2%vs.84.4%,P<0.001)和DFS(33.3%vs.81.5%,P<0.001)低于高TSR组。单、多因素分析显示:TSR和S-TLII是NPC患者OS和DFS的独立危险预后因素(P<0.05)。结论低TSR与低S-TLII是海南NPC患者不良预后因素,且二者相关,可为预后评估提供参考。Objective To investigate the distribution and the impact of tumor-stroma ratio(TSR)and stromal lymphocyte infiltrating intensity(S-TLII)on the prognosis of 107 patients with nasopharyngeal carcinoma(NPC)in Hainan province.Methods One hundred and seven NPC patients from 131 patients who were hospitalized in the First Affiliated Hospital of Hainan Medical University from January 2016 to December 2019 were selected.Demographic,clinicopathological,and prognostic data were collected.Based on the percentage limit of 50%,NPC patients were divided into low-TSR group(≤50%)and high-TSR group(>50%).The relationships between TSR and S-TLII to the disease-free survival(DFS)and overall survival(OS)of NPC patients were analyzed.Results The 1-year,3-year,and 5-year OS rates for 107 NPC patients were 91.5%,76.4%,and 70.5%,while those DFS rates were 86.9%,68.2%,and 62.6%,respectively.There were 42(39.3%)cases in the low TSR group and 65(60.7%)cases in the high TSR group.The OS(45.2%vs.84.4%,P<0.001)and DFS(33.3%vs.81.5%,P<0.001)of the low TSR group were significantly lower than those of the high TSR group.Both univariate and multivariate analysis revealed that TSR and S-TLII were independently associated with OS and DFS in NPC patients(P<0.05).Conclusion Low TSR and low S-TLII are independent risk factors for poor prognosis of Hainan NPC patients and are correlated with S-TLII,which can provide a reference for prognosis evaluation.

关 键 词：肿瘤间质比 鼻咽癌 预后 生存率 间质淋巴细胞浸润强度 

分 类 号：R739.62[医药卫生—肿瘤]