JAK/STAT信号通路及其抑制剂在瘢痕疙瘩治疗中的研究进展  

Advances in JAK/STAT Signaling Pathway and its Inhibitors in Keloid Therapy

作　　者：王启萌 任哲生 金文玉[1] 金哲虎[1] WANG Qimeng;REN Zhesheng;JIN Wenyu;JIN Zhehu(Department of Dermatology,Yanbian University Hospital,Yanji 133000,China)

机构地区：[1]延边大学附属医院皮肤科,吉林延吉133000

出　　处：《中国皮肤性病学杂志》2025年第3期330-335,共6页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金项目(82260617);吉林省教育厅科学研究项目(JJKH20240691KJ)。

摘　　要：瘢痕疙瘩是皮肤过度愈合的一种表现,具有类肿瘤特性,常伴有胶原蛋白的沉积。已有研究表明,Janus激酶(JAK)/信号转导与转录激活因子(STAT)信号通路在瘢痕疙瘩的形成中扮演着关键角色。本文从JAK/STAT通路参与调控瘢痕疙瘩相关的细胞因子、生长因子,及其代谢水平和关联基因等多个环节综述了该通路在其发病和治疗中的研究进展。并分析了国内外JAK/STAT通路的靶向药物研究现状,为瘢痕疙瘩的发病机制研究及相关药物开发提供参考。Keloids are a manifestation of excessive skin healing with tumor-like properties,often accompanied by collagen deposition.The Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway has been shown to play a key role in keloids′formation.In this paper,the research progress of the JAK/STAT pathway in the pathogenesis and treatment of keloid is reviewed from the aspects of the JAK/STAT pathway involved in the regulation of keloid-related cytokines,growth factors,and their metabolic levels and associated genes.We also analyzed the current status of JAK/STAT pathway targeting drugs both at home and abroad to provide reference for the pathogenesis of keloid and related drug development.

关 键 词：瘢痕疙瘩 JAK/STAT通路 白介素 生长因子 基因调控 

分 类 号：R739.5[医药卫生—肿瘤]