血清PAI-1、ANXA2水平与短暂性脑缺血发作患者颈动脉斑块稳定性的关系  

Relationship between serum PAI-1 and ANXA2 levels and carotid plaque stability in patients with transient ischemic attack

作　　者：赵全 钱时德 胡子奇 焦冬生 ZHAO Quan;QIAN Shide;HU Ziqi;JIAO Dongsheng(Department of Neurology,Eastern Theater Air Force Hospital,Nanjing,Jiangsu 210000,China)

机构地区：[1]东部战区空军医院神经科,江苏南京210000

出　　处：《国际检验医学杂志》2025年第5期543-547,共5页International Journal of Laboratory Medicine

基　　金：江苏省医学科研项目(S2020030)。

摘　　要：目的探讨血清纤溶酶原激活物抑制剂-1(PAI-1)、膜联蛋白A2(ANXA2)水平与短暂性脑缺血发作(TIA)患者颈动脉粥样硬化(CAS)斑块稳定性的关系。方法选取2021年1月至2023年1月该院收治的131例TIA患者为TIA组,另选取同期46例体检健康者为对照组,根据TIA患者CAS斑块稳定性分为不稳定组(64例)和稳定斑块/无斑块组(67例)。采用酶联免疫吸附试验检测血清PAI-1水平,化学发光免疫法检测血清ANXA2水平。多因素Logistic回归分析TIA患者CAS斑块稳定性的因素,受试者工作特征曲线分析血清PAI-1、ANXA2水平对TIA患者CAS不稳定性的预测价值。结果与对照组比较,TIA组血清PAI-1、ANXA2水平升高(P<0.05)。与稳定斑块/无斑块组比较,不稳定组血清PAI-1、ANXA2水平升高(P<0.05)。吸烟、TIA高风险、PAI-1水平升高、ANXA2水平升高为影响TIA患者CAS斑块稳定性的独立危险因素(P<0.05)。血清PAI-1、ANXA2水平联合预测的曲线下面积为0.879,大于血清PAI-1、ANXA2水平单独预测的0.788、0.783(P<0.05)。结论血清PAI-1、ANXA2水平升高与TIA患者CAS斑块不稳定密切相关,血清PAI-1、ANXA2水平联合预测TIA患者CAS斑块不稳定的价值较高。Objective To investigate the relationship between serum levels of plasminogen activator inhibitor-1(PAI-1)and annexin A2(ANXA2)and the carotid atherosclerosis stability(CAS)plaque in patients with transient ischemic attack(TIA).Methods A total of 131 patients with TIA admitted to the hospital from January 2021 to January 2023 were selected as the TIA group,and 46 healthy people in the same period were selected as the control group.According to the CAS plaque stability of TIA patients,they were divided into unstable plaque group(64 cases)and stable plaque/no plaque group(67 cases).The serum levels of PAI-1 and ANXA2 were detected by enzyme-linked immunosorbent assay and chemiluminescence immunoassay,respectively.Multivariate Logistic regression analysis was used to analyze the factors of CAS plaque stability in TIA patients.Receiver operating characteristic curve was used to analyze the predictive value of serum PAI-1 and ANXA2 levels for CAS instability in TIA patients.Results Compared with the control group,the levels of PAI-1 and ANXA2 in TIA group were significantly increased(P<0.05).Compared with the stable plaque/no plaque group,the unstable plaque group was significant increaseed in the serum levels of PAI-1 and ANXA2(P<0.05).Smoking,high risk of TIA,elevated PAI-1 and ANXA2 were independent risk factors for CAS plaque stability in patients with TIA(P<0.05).The area under the curve predicted by serum PAI-1 and ANXA2 levels combined was 0.879,which was larger than 0.788 and 0.783 predicted by serum PAI-1 and ANXA2 levels alone(P<0.05).Conclusion The increased levels of serum PAI-1 and ANXA2 are closely related to CAS plaque instability in patients with TIA.The combination of serum PAI-1 and ANXA2 levels has a higher value in predicting CAS plaque instability in patients with TIA.

关 键 词：短暂性脑缺血发作 纤溶酶原激活物抑制剂-1 膜联蛋白A2 颈动脉粥样硬化斑块稳定性 

分 类 号：R743.1[医药卫生—神经病学与精神病学]