结直肠癌患者血清IGFBP-3、GP73、CCSA-2表达与临床病理特征和预后的关系  

Relationship between serum IGFBP-3,GP73,CCSA-2 expression and clinicopathological features and prognosis in patients with colorectal cancer

作　　者：高秀侠 贾乐[2] GAO Xiuxia;JIA Le(Department of Pathology,Baoji High-Tech Hospital,Baoji,Shaanxi 721031,China;Department of Pathology,Baoji Hospital of Traditional Chinese Medicine,Baoji,Shaanxi 721001,China)

机构地区：[1]宝鸡高新医院病理科,陕西宝鸡721031 [2]宝鸡市中医医院病理科,陕西宝鸡721001

出　　处：《国际检验医学杂志》2025年第5期548-552,共5页International Journal of Laboratory Medicine

基　　金：陕西省科学技术厅科技计划项目(2021SF-214)。

摘　　要：目的探讨结直肠癌(CRC)患者血清胰岛素样生长因子结合蛋白-3(IGFBP-3)、高尔基体跨膜糖蛋白73(GP73)、结直肠癌特异性抗原-2(CCSA-2)的表达与临床病理特征和预后的关系。方法选取2019年1月至2020年12月于宝鸡高新医院及宝鸡市中医医院就诊的CRC患者80例为CRC组,另纳入同期的体检健康者80例作为对照组,采用酶联免疫吸附试验检测两组血清IGFBP-3、GP73和CCSA-2水平,收集CRC患者的临床资料,对所有患者进行为期3年的随访,采用Cox比例风险回归模型分析预后影响因素。结果CRC组血清IGFBP-3水平低于对照组(P<0.05),GP73、CCSA-2水平高于对照组(P<0.05)。血清IGFBP-3、GP73和CCSA-2水平与患者肿瘤最大径、分化程度、TNM分期及有无淋巴结转移有关(P<0.05)。IGFBP-3高表达、GP73和CCSA-2低表达患者的总生存率和无进展生存率均高于IGFBP-3低表达、GP73和CCSA-2高表达患者(P<0.05)。CRC患者的肿瘤最大径、分化程度、TNM分期、有无淋巴结转移及血清IGFBP-3、GP73、CCSA-2水平是CRC患者预后的影响因素(P<0.05)。结论血清IGFBP-3、GP73和CCSA-2水平与CRC患者的临床病理学特征及预后密切相关,有望成为预测和评估患者预后的重要生物学指标,可为临床早期诊断病情,尽早发现复发和转移,评估和预测患者预后提供一定的参考。Objective To investigate the expression of serum insulin-like growth factor binding protein-3(IGFBP-3),Golgi transmembrane protein 73(GP73)and colorectal cancer specific antigen-2(CCSA-2)in patients with colorectal cancer(CRC)and their relationship with clinicopathological features and prognosis.Methods A total of 80 patients with CRC in Baoji High-tech Hospital and Baoji Hospital of Traditional Chinese Medicine from January 2019 to December 2020 were selected as the CRC group,and 80 healthy people in the same period were included as the control group.Serum levels of IGFBP-3,GP73 and CCSA-2 were detected by enzyme-linked immunosorbent assay.All patients were followed up for 3 years.Cox proportional hazards regression model was used to analyze the prognostic factors.Results The level of serum IGFBP-3 in CRC group was lower than that in control group,and the levels of GP73 and CCSA-2 were higher than those in control group(P<0.05).The serum levels of IGFBP-3,GP73 and CCSA-2 were related to tumor size,differentiation degree,TNM stage and lymph node metastasis(P<0.05).The overall survival and progression-free survival rates of patients with high expression of IGFBP-3 and low expression of GP73 and CCSA-2 were significantly higher than those of patients with low expression of IGFBP-3 and high expression of GP73 and CCSA-2(P<0.05).Tumor size,differentiation degree,TNM stage,lymph node metastasis and serum levels of IGFBP-3,GP73 and CCSA-2 were the influencing factors for the prognosis of CRC patients(P<0.05).Conclusion The serum levels of IGFBP-3,GP73 and CCSA-2 are closely related to the clinicopathological characteristics and prognosis of CRC patients,and are expected to become important biological indicators for predicting and evaluating the prognosis of patients.They can provide certain reference for early diagnosis of disease,early detection of recurrence and metastasis,and evaluation and predicting the prognosis of patients.

关 键 词：结直肠癌 血清胰岛素样生长因子结合蛋白-3 高尔基体跨膜糖蛋白73 结直肠癌特异性抗原-2 预后 

分 类 号：R735.3[医药卫生—肿瘤]