肥胖食蟹猴一般身体指标、血糖、血脂的动态监测及相关性分析  

Dynamic Monitoring and Correlation Analysis of General Body Indicators,Blood Glucose,and Blood Lipid in Obese Cynomolgus Monkeys

作　　者：韦炎冶 申果 张鹏飞 石松平 胡家豪 张绪哲 花慧源 花冠洋 陆宏正 曾勇 季风 韦祝梅 WEI Yanye;SHEN Guo;ZHANG Pengfei;SHI Songping;HU Jiahao;ZHANG Xuzhe;HUA Huiyuan;HUAGuanyang;LU Hongzheng;ZENG Yong;JI Feng;WEI Zhumei(Guangxi Huaren Jiying Biotechnology Co.,Ltd.,Nanning 530000,China;Guangxi Academy of Sciences,Nanning 530007,China;Laibin Xingui Biotechnology Co.,Ltd.,Laibin 546108,China;Guangxi Huaren Medical Science and Technology Group,Nanning 530000,China)

机构地区：[1]广西华仁济瀛生物科技有限公司,南宁530000 [2]广西科学院,南宁530007 [3]来宾市新桂生物科技有限公司,来宾546108 [4]广西华仁医学科技集团,南宁530000

出　　处：《实验动物与比较医学》2025年第1期30-36,共7页Laboratory Animal and Comparative Medicine

基　　金：南宁市良庆区重点科技计划专项“食蟹猴代谢异常疾病模型研究”(202309)。

摘　　要：目的通过检测肥胖型食蟹猴的一般身体指标与血糖、血脂的动态变化,探究各指标之间相关性,为肥胖食蟹猴模型研究提供参考依据。方法选取5~17岁的正常雄性食蟹猴30只(体重指数<35 kg/m^(2)且糖化血红蛋白含量<4.50%)和自发性肥胖雄性食蟹猴99只(体重指数≥35 kg/m^(2)且糖化血红蛋白含量<4.50%),连续3年监测其腹围、皮脂厚度、体重、体重指数、空腹血糖、糖化血红蛋白以及血脂四项指标,并使用重复测量方差分析、简单线性回归和多元线性回归相关性分析方法分析各指标间的相关性。结果与正常食蟹猴相比,肥胖食蟹猴的腹围、皮脂厚度、体重、体重指数和甘油三酯水平均显著升高(均P<0.05);正常食蟹猴的皮脂厚度逐年上升,其余指标维持稳定。与第1年相比,肥胖食蟹猴第2年腹围、皮脂厚度、体重、体重指数、甘油三酯和空腹血糖水平显著升高(均P<0.05),且升高趋势在第3年持续存在(均P<0.05)。正常食蟹猴第2、3年的肥胖发生率分别为16.67%和23.33%,糖尿病的发病率均为16.67%。肥胖食蟹猴第2、3年糖尿病的发病率分别为29.29%、44.44%,其中在11~13岁群体发病率分别为36.36%、44.68%,大于13岁群体的发病率(分别为28.13%和51.35%)。相关性分析结果显示,糖尿病发病组食蟹猴的空腹血糖与年龄、腹围、皮脂厚度、体重、甘油三酯水平均显著相关(均P<0.05)。结论长期肥胖可导致食蟹猴的一般身体指标及空腹血糖水平升高,并增加糖尿病的发病率;在肥胖引起的糖尿病食蟹猴中,其空腹血糖与年龄、体重、腹围、皮脂厚度、甘油三酯水平均高度相关,这对于预测自发性糖尿病的发生有一定意义。Objective This study aims to investigate the dynamic changes in general body parameters,blood glucose,and blood lipid profiles in obese cynomolgus monkeys,exploring the correlations among these parameters and providing a reference for research on the obese cynomolgus monkey model.Methods 30 normal male cynomolgus monkeys aged 5-17 years old(with body mass index<35 kg/m^(2)and glycated hemoglobin content<4.50%)and 99 spontaneously obese male cynomolgus monkeys(with body mass index≥35 kg/m^(2)and glycated hemoglobin content<4.50%)were selected.Over a period of three years,their abdominal circumference,skinfold thickness,body weight,body mass index,fasting blood glucose,glycated hemoglobin,and four blood lipid indicators were monitored.The correlations between each indicator were analyzed using repeated measurement ANOVA,simple linear regression,and multiple linear regression correlation analysis method.Results Compared to the control group,the obese group exhibited significantly higher levels of abdominal circumference,skinfold thickness,body weight,body mass index,and triglyceride(P<0.05).In the control group,skinfold thickness increased annually,while other indicators remained stable.Compared with the first year,the obese group showed significantly increased abdominal circumference,skinfold thickness,body weight,body mass index,triglyceride,and fasting blood glucose in the second year(P<0.05),with this increasing trend persisting in the third year(P<0.05).In the control group,the obesity incidence rates in the second and third years were 16.67%and 23.33%,respectively,while the prevalence of diabetes remained at 16.67%.In the obese group,the diabetes incidence rates were 29.29%and 44.44%in years 2 and 3,respectively.Among the 11-13 year age group,the incidence rates were 36.36%and 44.68%,while for the group older than 13 years,the rates were 28.13%and 51.35%.Correlation analysis revealed significant associations(P<0.05)between fasting blood glucose and age,abdominal circumference,skinfold thickness,body weight,a

关 键 词：肥胖 食蟹猴 身体指标 血糖 血脂 相关性分析 

分 类 号：Q95-33[生物学—动物学] R-332[医药卫生]