口腔微生物组的致病机制及影响因素研究进展  

Research progress on the pathogenic mechanisms and influencing factors of the oral microbiome

作　　者：熊雨婷 潘已汇 兰红 闫香珍 XIONG Yuting;PAN Yihui;LAN Hong;YAN Xiangzhen(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Periodontal,Shanghai Tongji Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)

机构地区：[1]上海市同济口腔医院牙周病科,同济大学口腔医学院,上海牙组织修复与再生工程技术研究中心,同济大学口腔医学研究所,上海200072

出　　处：《同济大学学报(医学版)》2025年第1期125-131,共7页Journal of Tongji University(Medical Science)

基　　金：国家自然科学基金青年科学基金项目(81900978)。

摘　　要：口腔微生物组与口腔疾病及全身疾病密切相关,其相关机制包括生态失调、炎症反应、毒素因子、微生物易位、免疫系统紊乱等多个方面。影响和调节口腔微生物组的因素有很多,包括遗传、年龄、性别、种族、环境、饮食、吸烟、口腔卫生、牙周治疗、药物等。本文综述了口腔微生物组与全身疾病相关性及可能机制,并阐述了影响和调节口腔微生物组因素。全面了解这些因素有助于维持口腔微生物组的稳定,从而对口腔及全身健康产生积极影响。The oral microbiome is closely associated with oral and systemic diseases,the mechanisms include dysbiosis,inflammatory response,toxin factors,microbial translocation colonization and disorders of the immune system.Many factors influence or regulate the oral microbiome,including genetics,age,gender,ethnicity,environment,diet,smoking,oral hygiene,periodontal therapy,and medications.This review encapsulates the associations between the oral microbiome and systemic diseases,along with its potential mechanisms.It delineates the factors that influence or regulate the oral microbiome.A comprehensive comprehension of these factors may contribute to preserving the equilibrium of the oral microbiome,thereby exerting a favorable impact on oral health and furtherly the whole body.

关 键 词：口腔微生物组 口腔疾病 全身疾病 生态失调 炎症反应 

分 类 号：R781[医药卫生—口腔医学]