类风湿性关节炎实验模型研究进展  

Advances in experimental models of rheumatoid arthritis

作　　者：王俊伟 耿兴超[1] 李伟[1] WANG Junwei;GENG Xingchao;LI Wei(Institute for Safety Evaluation,National Institutes for Food and Drug Control,Beijing Key Laboratory for Safety Evaluation of Drugs,Beijing 100176,China;State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]中国食品药品检定研究院安全评价研究所,药物非临床安全评价研究北京市重点实验室,北京100176 [2]中国药科大学多靶标天然药物全国重点实验室,南京210009

出　　处：《中国实验动物学报》2025年第1期127-140,共14页Acta Laboratorium Animalis Scientia Sinica

基　　金：药品监管科学全国重点实验室项目(2023SKLDRS0126)。

摘　　要：类风湿性关节炎(rheumatoid arthritis,RA)是一种严重影响关节的慢性自身免疫性疾病,实验模型是研究RA发生机制、药理毒理机制和药物筛选评价的重要工具。目前常用的RA实验模型分为动物模型和体外模型,随着生物技术和生物材料的发展,RA实验模型已从诱导性模型和2D体外模型发展至自发性基因修饰模型和3D体外模型,中医病证结合模型的研究也取得了一定的进展。本文对RA实验模型的造模、监测和评价方法的研究进展进行总结,以期对RA相关研究提供参考。Rheumatoid arthritis(RA)is a chronic autoimmune disease that significantly impacts joints.Experimental models are crucial tools for studying the pathogenesis and pharmaco-toxicological mechanisms of RA and screening RA drugs.Commonly used experimental RA models include animal models and in vitro models.With advancements in biotechnology and biomaterials,experimental RA models have evolved from induced and 2D in vitro models to spontaneous gene modification and 3D in vitro models.Moreover,some progress has been made in the study of traditional Chinese medicine disease and syndrome combination models.This paper summarizes the research progress made in the modeling,monitoring,and evaluation of experimental RA models to provide a reference for related research.

关 键 词：类风湿性关节炎 动物模型 体外模型 诱导性模型 

分 类 号：Q95-33[生物学—动物学]