姜黄素的抗氧化性对视网膜退行性疾病的影响  

Effects of antioxidant activity of curcumin in retinal degenerative diseases

作　　者：许莞菁 孙雨浩 赵军[3] XU Wanjing;SUN Yuhao;ZHAO Jun(Department of Ophthalmology,QingPu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201799,China;Department of Otolaryngology,QingPu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201799,China;Department of Ophthalmology,Linyi People's Hospital,Linyi 276000,Shandong,China)

机构地区：[1]复旦大学附属中山医院青浦分院眼科,上海201799 [2]复旦大学附属中山医院青浦分院耳鼻咽喉科,上海201799 [3]临沂市人民医院眼科,山东临沂276000

出　　处：《山东大学耳鼻喉眼学报》2025年第1期146-151,共6页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：视网膜退行性疾病的病因和发病机制十分复杂,其中氧化应激因素造成的损伤不容忽视。姜黄素是具有多种生物活性的一种天然化合物,由于分子结构特殊,姜黄素可以清除活性氧并激活抗氧化防御系统,并且由于亲脂性强,姜黄素可以通过血-视网膜屏障作用于视网膜,故其对视网膜退行性疾病的治疗具备极高的研究价值。本文主要就姜黄素的抗氧化特性在几种视网膜退行性疾病中的应用以及相关研究进展作一综述。The etiology and pathogenesis of retinal degenerative diseases are very complex,and the damage caused by oxidative stress cannot be ignored.Curcumin is a natural compound with a variety of biological activities.Owing to its distinct molecular structure,curcumin can scavenge reactive oxygen species and activate the antioxidant defense system.Moreover,because of its strong lipophilicity,curcumin can cross the blood-retinal barrier and act on the retina.Therefore,it has a high research value in the treatment of retinal degenerative diseases.This article reviews the application and related research progress of the antioxidant properties of curcumin in several retinal degenerative diseases.

关 键 词：视网膜退行性疾病 抗氧化 姜黄素 活性氧 

分 类 号：R775[医药卫生—眼科]