卵母细胞成熟及其受精过程关键基因的研究进展  

Progress on key genes in oocyte maturation and its fertilization process

作　　者：陈佳瑶 张志平[2] 王诗敏 朱鹏飞 武学清[2] Chen Jiayao;Zhang Zhiping;Wang Shimin;Zhu Pengfei;Wu Xueqing(Center for Clinical Discipline Construction,Shanxi Medical University,Taiyuan030001,China;Center of Reproductive Medicine,Children's Hospital of Shanxi,Women Health Center of Shanxi,Taiyuan030013,China)

机构地区：[1]山西医科大学临床学科建设中心,太原030001 [2]山西省儿童医院、山西省妇幼保健院生殖医学中心,太原030013

出　　处：《中华生殖与避孕杂志》2025年第1期90-95,共6页Chinese Journal of Reproduction and Contraception

基　　金：山西省生殖与遗传研究科技培育团队项目(2020TD19);山西省2023年度研究生教育创新计划各类项目(2023KY424)。

摘　　要：卵母细胞成熟障碍和受精失败是由多种因素引起的,包括染色体异常和卵母细胞质量不佳等复杂因素。随着高通量测序技术的广泛应用,越来越多的基因突变被发现与不孕患者的卵母细胞成熟及受精过程有关。本文总结并讨论了11个有关卵母细胞成熟和受精相关的女性关键基因(TRIP13、TBPL2、LHX8、PATL2、TUBB8、CDC20、WEE2、ZP、ASTL、JUNO和CD9),为研究卵母细胞成熟阻滞和受精失败相关疾病的预防和开发靶向治疗提供基础。Oocyte maturation disorders and fertilization failures are caused by a variety of factors,including complex factors such as chromosomal abnormalities and poor oocyte quality.With the widespread use of high-throughput sequencing technology,more and more genetic mutations have been found to be associated with oocyte maturation and fertilization process in infertile patients.This paper summarizes and discusses 11 key genes(TRIP13,TBPL2,LHX8,PATL2,TUBB8,CDC20,WEE2,ZP,ASTL,JUNO and CD9)related to oocyte maturation and fertilization-related disorders in females,providing a basis for research on the prevention of diseases associated with oocyte maturation blockage and fertilization failure and the development of targeted therapies.

关 键 词：受精 卵母细胞成熟 基因突变 

分 类 号：R711[医药卫生—妇产科学]