针刺治疗烟草依赖的潜在神经生物学作用机制研究现状及展望  

Current Status and Prospects of Research on the Potential Neurobiological Mechanisms of Acupuncture in the Treatment of Tobacco Dependence

作　　者：陈淑敏 畅金 谭超仁 朱浩 杨金生[3] 刘朝[4] 王莹莹[1] CHEN Shumin;CHANG Jin;TAN Chaoren;ZHU Hao;YANG Jinsheng;LIU Zhao;WANG Yingying(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing,100700;Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences;Shaanxi University of Chinese Medicine;Department of Smoking Control and Respiratory Disease Prevention and Control,China-Japan Friendship Hospital)

机构地区：[1]中国中医科学院针灸研究所,北京市100700 [2]中国中医科学院中医基础理论研究所 [3]陕西中医药大学 [4]中日友好医院控制吸烟与呼吸疾病防控部

出　　处：《中医杂志》2025年第4期421-426,共6页Journal of Traditional Chinese Medicine

基　　金：首都卫生发展科研专项(2024-2-4372,2022-1-4281);国家中医药管理局青年岐黄基金专项(11055);中国中医科学院科技创新工程(CI2021A03506)。

摘　　要：从针刺对烟草依赖行为的调节、针刺对戒断综合征的影响、针刺对烟草依赖复吸的预防三个重要环节综合阐述针刺治疗烟草依赖的潜在神经生物学作用机制。发现针刺可以通过调节奖赏通路多巴胺等相关神经元来抑制自我觅药行为,从而调节烟草依赖行为;通过改善戒烟者口腔环境,缓解戒断后负性情绪,来改善戒断症状;通过降低吸烟渴求相关脑网络活动,改善成瘾记忆等认知脑功能来预防复吸。目前针刺治疗烟草依赖具体神经生物作用机制以及神经环路研究尚有限,提出未来研究方向为评价临床作用特点,探索具体疗效机制;基于脑部病理变化,加强脑功能探索;结合现代技术,明确针刺干预的神经环路,为针刺治疗烟草成瘾提供依据。This paper comprehensively discusses on the potential neurobiological mechanisms of acupuncture in the treatment of tobacco dependence,focusing on three important aspects,including acupuncture's regulation of tobacco dependence behavior,effects of acupuncture on withdrawal syndrome,and the role of acupuncture in preventing relapse.It is found that acupuncture can inhibit drug-seeking behavior by regulating the reward pathway and related neurons,such as dopamine,thus modulating tobacco dependence behavior.It also alleviates withdrawal symptoms by improving the oral environment of smokers and reducing negative emotions after quitting.Furthermore,acupuncture can prevent relapse by decreasing brain network activity related to smoking cravings and improving cognitive brain functions like addiction memory.Currently,research on the specific neurobiological mechanism of acupuncture in treating tobacco dependence and the involved neural circuits is limited.Future research directions are proposed,including the evaluation of clinical effects,exploration of specific therapeutic mechanisms,investigation of brain pathology,and strengthening the exploration of brain functions.Additionally,combining modern technologies to clarify the neural circuits involved in acupuncture intervention will provide a basis for acupuncture treatment of tobacco addiction.

关 键 词：烟草依赖 针刺 神经生物学 

分 类 号：R246.6[医药卫生—针灸推拿学]