中西医学视角下探讨儿童癫痫发生的防治思路  

Prevention and Treatment Ideas of Epileptogenesis in Children under the Perspective of Traditional Chinese Medicine and Western Medicine

作　　者：陈汉江[1] 戎萍[1] 张喜莲[1] 胡思源[1] 马融[1] CHEN Hanjiang;RONG Ping;ZHANG Xilian;HU Siyuan;MA Rong(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine/National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin,300181)

机构地区：[1]天津中医药大学第一附属医院/国家中医针灸临床医学研究中心,天津市300181

出　　处：《中医杂志》2025年第3期251-255,共5页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81904251,82174434)。

摘　　要：癫痫发生是由正常的发育脑向病理性的癫痫脑逐步进展的动态过程,是癫痫的潜伏期和萌芽阶段。结合现代医学和中医学对儿童癫痫发生的认识,提出体质从化、病痰致痫、脑络受损观点,分别与基因多态性、免疫炎症、血脑屏障微血管障碍具有相关性,为儿童癫痫发生的关键病理机制。并据此探讨儿童癫痫发生的防治思路与研究方向。Epileptogenesis is a dynamic process of gradual progression from normal developing brain to pathologi-cal epileptic brain,which is the latent and budding stage of epilepsy.Combining the understanding of epileptogenesis in children from Western medicine and traditional Chinese medicine(TCM),we proposed that the viewpoints of con-stitutional transformation,phlegm pathogen inducing epilepsy,and brain collateral damage,which correspond to key pathological mechanisms,namely gene polymorphism,immunoinflammation,and microvascular dysfunction of the blood-brain barrier,respectively.Based on these insights,strategies for prevention and treatment of epileptogenesis in children,as well as potential research directions are explored.

关 键 词：癫痫发生 体质 基因多态性 免疫炎症 血脑屏障 痰伏脑络 

分 类 号：R742.1[医药卫生—神经病学与精神病学]