A comprehensive visual report of urodynamic study in rats with spinal cord injury  

作　　者：Hanieh Salehi-Pourmehr Javad Mahmoudi Arman Saeedi Vahdat Sakineh Hajebrahimi Nasrin Abolhasanpour 

机构地区：[1]Student Research Committee,Tabriz University of Medical Sciences,Tabriz,Iran [2]Research Center for Evidence-based medicine,Iranian EBM Centre:A Joanna Briggs Institute(JBI)Center of Excellence,Tabriz University of Medical Sciences,Tabriz,Iran [3]Neurosciences Research Center,Tabriz University ofMedical Sciences,Tabriz,Iran [4]Department of Oral andMaxillofacial Radiology,Dentistry Faculty,Tabriz University of Medical Sciences,Tabriz,Iran [5]Urology Department,Faculty of Medicine,Tabriz University of Medical Sciences,Tabriz,Iran

出　　处：《Current Urology》2025年第1期59-63,共5页当代泌尿学(英文)

基　　金：a financial support from the Student Research Committee of Tabriz University of Medical Sciences(grant no.63880).

摘　　要：Objectives:Spinal cord injury(SCI)is one of the most debilitating and expensive traumatic conditions.Chronic complications after SCI have a particularly negative impact on patients’functional independence and quality of life.Urodynamic study(UDS)provides a quantitative assessment of lower urinary tract function in these patients.In many fields,animal models are considered a precursor to clinical trials,so research using laboratory animals play a major role in knowledge acquisition.Materials and methods:Twelve femaleWistar rats(13 weeks old,220-270 g)were divided randomly into 2 groups:sham or SCI.The sham-operated group underwent a laminectomy at T9-T10 without any spinal cord damage,while the SCI group underwent a complete transection at the T9-T10 vertebral level.We performed cystometry in all animals at the end of the fourth week.In this article,we visualize all procedures for catheter implementation and UDS in animals for the first time at Tabriz University of Medical Sciences,Iran,using a locally developed animal UDS device.Results:The UDS results showed that the bladders in the SCI group were overactive and that peak and baseline pressures increased significantly in rats with SCI when compared with the sham group(p<0.05 for all).Conversely,significant reductions in bladder compliance and intercontraction interval were observed in the SCI group(p<0.05 for both).Conclusions:This comprehensive visual report will be very useful to all researchers in the field of urology.Furthermore,the measurable variables of the UDS device have been described in this study.

关 键 词：Spinal cord injury Bladder function CYSTOMETRY URODYNAMICS RATS 

分 类 号：R651.2[医药卫生—外科学]