术前血清尿酸/白蛋白比值与结直肠癌术后患者预后的相关性分析  

Correlation analysis between preoperative serum uric acid to albumin ratio and prognosis of patients with colorectal cancer after operation

作　　者：叶学坤 何磊 李瑞 林志浩 Ye Xuekun;He Lei;Li Rui;Lin Zhihao(Department of Gastrointestinal Surgery,the Third Affiliated Hospital of Anhui Medical University,Hefei First People's Hospital,Hefei 230000)

机构地区：[1]安徽医科大学第三附属医院,合肥市第一人民医院胃肠外科,安徽合肥230000

出　　处：《中国现代医药杂志》2025年第2期21-26,共6页Modern Medicine Journal of China

摘　　要：目的探讨血清尿酸/白蛋白比值(Uric acid/albumin ratio,UAR)与结直肠癌术后患者的预后有无相关性。方法收集2018年9月~2021年9月于我院行根治性结直肠癌手术患者206例的资料,分为存活组(n=188)和死亡组(n=18),比较两组患者临床资料。采用单因素Logistic及多因素分析影响结直肠癌患者术后3年死亡的因素。使用受试者工作特征(Receiver operating characteristic curve,ROC)曲线计算曲线下面积(Area under the curve,AUC),比较术前尿酸、白蛋白、术前与术后UAR对结直肠癌术后患者预后的预测效能。结果多因素分析结果显示,术前UAR(OR=1.82,95%CI:1.16~2.87,P=0.010)、术后UAR(OR=1.25,95%CI:1.05~1.49,P=0.013)是影响结直肠癌术后患者预后的独立危险因素。ROC曲线分析结果显示,术前UAR预测结直肠癌术后患者术后3年死亡的AUC为0.831(95%CI:0.714~0.948);敏感度为72.20%,特异度为90.40%。术后UAR预测患者术后3年死亡的AUC为0.759(95%CI:0.602~0.915);敏感度为66.70%,特异度为97.30%。高UAR组预测术后3年死亡的AUC为0.838(95%CI:0.726~0.951),敏感度为92.90%,特异度为67.30%。低UAR组预测术后3年死亡的AUC为0.571(95%CI:0.319~0.824),敏感度为75.00%,特异度为57.90%。结论术前UAR是预测结直肠癌术后患者预后的独立危险因素。术前高UAR患者预后较差,高UAR对结直肠癌术后患者预后3年死亡风险有一定的预测价值。Objective To investigate whether the ratio of serum uric acid to albumin(UAR)was correlated with the prognosis of patients with colorectal cancer after surgery.Methods A total of 206 patients undergoing radical colorectal cancer surgery in our hospital from Sep 2018 to Sep 2021 were collected,and all patients were divided into survival group(n=188)and death group(n=18).The clinical data were compared between the two groups.Univariate multivariate Logistic regression analysis were used to analyze the factors affecting the prognosis and mortality of postoperative patients with colorectal cancer.The area under the curve(AUC)was calculated using receiver operating characteristics(ROC)curve to compare the predictive efficacy of uric acid,albumin,and the UAR before and after surgery for postoperative mortality in patients with colorectal cancer.Results Multivariate analysis showed that preoperative UAR level(OR=1.82,95%CI:1.16~2.87,P=0.010)and postoperative UAR level(OR=1.25,95%CI:1.05~1.49,P=0.013)were independent factors influencing the prognosis of colorectal cancer patients after surgery.ROC curve analysis showed that the AUC of preoperative UAR for predicting postoperative mortality of colorectal cancer was 0.831(95%CI:0.714~0.948),the sensitivity was 72.20%,and the specificity was 90.40%.The AUC of postoperative UAR predicting mortality was 0.759(95%CI:0.602~0.915),the sensitivity was 66.70%,and the specificity was 97.30%.The AUC of predicting 3-year mortality in the high UAR group was 0.838(95%CI:0.726~0.951),the sensitivity was 92.90%,and the specificity was 67.30%.In the low UAR group,the AUC of predicting 3-year postoperative mortality was 0.571(95%CI:0.319~0.824),the sensitivity was 75.00%,and the specificity was 57.90%.Conclusion Preoperative UAR is an independent risk factor for predicting the prognosis of patients with colorectal cancer after surgery.The prognosis of patients with high UAR before operation is poor,and high UAR has a certain predictive value for the 3-year mortality risk of patients with c

关 键 词：血清尿酸与白蛋白比值 结直肠肿瘤 预后相关性 

分 类 号：R735.34[医药卫生—肿瘤]