血管内介入溶栓术对急性脑梗死患者PPARγ水平、血小板功能及神经功能的影响  

Effects of intravascular interventional thrombolysis on the level of PPARγ,platelet function and neurological function in patients with acute cerebral infarction

作　　者：王铁军 任伟超 段春苗 陈左然 WANG Tie-jun;REN Wei-chao;DUAN Chun-miao(Department of Neurology,Daxing Teaching Hospital,Capital Medical University,Beijing 102600,China)

机构地区：[1]首都医科大学大兴教学医院神经内科,北京102600

出　　处：《临床和实验医学杂志》2025年第3期225-229,共5页Journal of Clinical and Experimental Medicine

基　　金：首都卫生发展科研专项项目(编号:首发2023-2Y-004);北京市大兴区人民医院科技项目(编号:4202130393,4202215428)。

摘　　要：目的探讨血管内介入溶栓术对急性脑梗死(ACI)患者过氧化物酶体增殖物激活受体(PPARγ)水平、血小板功能及神经功能的影响。方法回顾性选取2022年6月至2023年12月首都医科大学大兴教学医院神经内科收治的ACI患者99例,按照治疗方法不同分为研究组(n=48)和对照组(n=51)。研究组采用血管内介入溶栓术治疗,对照组采用静脉溶栓治疗。观察两组患者治疗前和治疗后10、20、30 d的神经功能[美国国立卫生研究院卒中量表(NIHSS)评分]、日常生活能力[日常生活活动(ADL)评分],治疗前、治疗后30 d的血清血小板聚集率(PAgT)、血小板黏附率(PAdT)及B型钠尿肽(BNP)、同型半胱氨酸(Hcy)、PPARγ水平以及生活质量[健康调查量表36(SF-36)评分]。结果治疗后10、20、30 d,两组患者的NIHSS评分均明显低于治疗前,且研究组患者的NIHSS评分均明显低于对照组,差异均有统计学意义(P<0.05)。治疗后10、20、30 d,两组患者ADL评分均明显高于治疗前,且研究组患者ADL评分均高于对照组,差异均有统计学意义(P<0.05)。治疗后30 d,两组患者血清PAgT、PAdT水平均低于治疗前,且研究组患者血清PAgT、PAdT水平分别为(32.48±3.85)%、(34.85±3.12)%,均低于对照组[(34.98±4.37)%、(37.28±3.63)%],差异均有统计学意义(P<0.05)。治疗后30 d,两组患者血清PPARγ、BNP、Hcy水平均低于治疗前,且研究组患者血清PPARγ、BNP、Hcy水平分别为(37.47±9.31)pg/mL、(194.35±1.48)pg/mL、(14.38±2.63)μmol/L,均低于对照组[(38.51±9.25)pg/mL、(231.36±1.45)pg/mL、(19.74±2.25)μmol/L],差异均有统计学意义(P<0.05)。治疗后30 d,除对照组患者SF-36评分中情感职能、精神健康评分与治疗前比较,差异均无统计学意义(P>0.05)外,两组其他评分均高于治疗前,差异均有统计学意义(P<0.05);研究组患者治疗后30 d的各项SF-36评分均高于对照组,差异均有统计学意义(P<0.05)。结论与静脉溶栓治疗相比,血Objective To investigate the effects of intravascular interventional thrombolysis on the level of peroxisome proliferator-activated receptors(PPARγ),platelet function and neurological function in patients with acute cerebral infarction(ACI).Methods A total of 99 ACI patients admitted to the Department of Neurology,Daxing Teaching Hospital,Capital Medical University from June 2022 to December 2023 were retrospectively selected and divided into the study group(n=48)and the control group(n=51)according to different treatment methods.Intravascular interventional hemolysis was performed in the study group,and intravenous thrombolysis was performed in the control group.The neurological function[National Institute of Health stroke scale(NIHSS)score]and daily living ability[activity of daily living(ADL)score]before treatment and 10,20,30 days after treatment,the levels of serum platelet aggregation rate(PAgT),platelet adhesion rate(PAdT),B-type natriuretic peptide(BNP),homocysteine(Hcy),PPARγand quality of life[36-Item Short Form Health Survey(SF-36)score]before and 30 days after treatment of the two groups were compared.Results At 10,20 and 30 days after treatment,the NIHSS scores of the two groups were significantly lower than those before treatment,and the NIHSS score of the study group was significantly lower than that of the control group,the differences were statistically significant(P<0.05).At 10,20 and 30 days after treatment,the ADL scores of the two groups were significantly higher than those before treatment,and the ADL scores of the study group were higher than those of the control group,the differences were statistically significant(P<0.05).At 30 days after treatment,the levels of serum PAgT and PAdT in the two groups were lower than those before treatment,and the levels of serum PAgT and PAdT in the study group were(32.48±3.85)%and(34.85±3.12)%,respectively,which were lower than those in the control group[(34.98±4.37)%,(37.28±3.63)%],the differences were statistically significant(P<0.05).At 30 days af

关 键 词：脑梗死 过氧化物酶体增殖物激活受体 血管内介入溶栓术 血小板功能 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]