林奇综合征患者结直肠癌治疗需要面对的问题  

Problems to be faced in the treatment of colorectal cancer in patients with Lynch syndrome

作　　者：王振军[1] Wang Zhenjun(Department of General Surgery,Affiliated Beijing Chaoyang Hospital,Capital Medical University,Beijing100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院普外科,北京100020

出　　处：《中华普通外科杂志》2025年第2期85-87,共3页Chinese Journal of General Surgery

摘　　要：新近的免疫治疗和靶向免疫联合治疗的成功, 对以错配修复缺陷为分子病理学特征的林奇综合征患者的结直肠癌乃至其他相关癌的传统治疗模式的改变进一步显示了多学科诊疗模式的重要性, 促使临床医师对合适的患者首先选择药物治疗, 并发展能够准确判断疗效的方法, 研究是否应该采取"缩小版"的根治手术来达到根治治疗的目的, 并研究可否采用程序性死亡受体1抑制剂预防林奇综合征恶性肿瘤发生, 更大限度地达到保留器官功能的目的。The success of recent immunotherapy and target immunotherapy further shows the importance of MDT model for colorectal cancer and other related cancers in patients with Lynch syndrome characterized by mismatch repair defect molecular pathology,which urges doctors to first choose targeted drug for suitable patients and develop methods that can accurately judge the curative effect,to study whether we should adopt the"down-scaled version"radical surgery to achieve the goal of radical cure,and to study whether PD-1 inhibitors can prevent the occurrence of Lynch syndrome malignant tumor and achieve organ preservation to a greater extent.

关 键 词：结直肠肿瘤 综合征 

分 类 号：R735.34[医药卫生—肿瘤]