氧化纳米铈促进氧化应激状态下口腔骨缺损修复的研究进展  

Progress of cerium oxide nanoparticles to promote the repair of oral bone defects under oxidative stress states

作　　者：王馨悦 王卓然 古丽莎[1] Wang Xinyue;Wang Zhuoran;Gu Lisha(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Stomatology,Guangdong Provincial Clinical Research Center of Oral Diseases,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广东省口腔疾病临床医学研究中心,广州510055

出　　处：《中华口腔医学研究杂志(电子版)》2025年第1期62-69,共8页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：广东省自然科学基金(2024A1515010071)。

摘　　要：氧化应激是生物体内氧化与抗氧化作用失衡的一种状态,其中活性氧(ROS)的过量产生可对DNA和蛋白质等生物大分子造成损害,进而影响心脏、骨等多种器官的功能。研究认为,氧化应激是多种口腔疾病发生与发展的重要危险因素,可引起骨稳态功能障碍,通过抑制成骨细胞活性和促进破骨细胞活动,加剧骨质吸收、阻碍口腔骨组织的愈合过程,甚至加剧口腔骨缺损,从而影响口腔结构与功能的完整性。氧化纳米铈颗粒(CNP)作为一种金属氧化物类的纳米粒子(NP),其表面存在Ce^(3+)和Ce^(4+)两种氧化态,能在两种价态间转换,且具有多种抗氧化酶模拟活性,因而具备清除ROS的能力。研究表明,CNP对于癌症、糖尿病等氧化应激相关疾病的治疗具有积极作用。本综述旨在探讨CNP的抗氧化应激作用及其对口腔成骨微环境的影响,为CNP在治疗口腔炎性骨缺损方面的研究和临床应用提供理论参考。Oxidative stress is a state in which there is an imbalance between oxidative and antioxidant effects in the body.Excessive production of reactive oxygen species(ROS)can damage deoxyribonucleic acid(DNA),proteins,etc,thereby impairing the function of many organs.It is now believed that oxidative stress,as a risk factor,is closely related to the development of a variety of oral diseases,and can cause bone homeostasis dysfunction,inhibit osteoblasts from forming bone and promote osteoclast activity,thus preventing oral bone healing and even exacerbating bone defects,and affecting the normal structure and function of oral cavity.Cerium oxide nanoparticles(CNPs),as a kind of metal oxide-based nanoparticles(NPs),have the ability to scavenge ROS due to the presence of two interchangeable oxidation states,Ce^(3+) and Ce^(4+),and the mimetic activity of various antioxidant enzymes.It is currently believed that CNPs have a promotive effect on the treatment of the diseases related to oxidative stress,such as cancer and diabetes mellitus,etc.Therefore,the aim of this article was to provide a review of the anti-oxidative stress effect of CNPs and its impact on the oral osteogenic microenvironment under oxidative stress,with a view to providing references to the research and clinical application of CNPs in the treatment of inflammatory bone defects in the oral cavity.

关 键 词：氧化应激 氧化纳米铈颗粒 口腔疾病 成骨微环境 

分 类 号：R782.4[医药卫生—口腔医学]