高分辨磁共振成像在颅内动脉粥样硬化卒中斑块诊断及发病机制中的应用  

Application of high-resolution magnetic resonance imaging in plaque diagnosis and pathogenesis identification for intracranial atherosclerosis-related stroke

作　　者：解正绮(综述) 武剑(审校) XIE Zhengqi;WU Jian(The First Hospital of Hebei Medical University,Shijiazhuang 050030,China)

机构地区：[1]河北医科大学第一医院,河北石家庄050030 [2]北京清华长庚医院,北京102218

出　　处：《中风与神经疾病杂志》2025年第2期187-192,共6页Journal of Apoplexy and Nervous Diseases

摘　　要：颅内动脉粥样硬化(ICAS)是世界缺血性卒中的主要原因。临床上ICAS主要通过影像学检查进行识别。近年来,高分辨率磁共振血管壁成像(HRMR-VWI)已逐步成为评估ICAS斑块特征的重要手段,且随着HRMR VWI的应用,对于急性缺血性卒中发病机制的诊断越来越准确,从而为卒中的二级预防与临床个体化治疗提供参考。本文系统综述了HRMR VWI中ICAS斑块主要成分的影像学表现,总结了HRMR技术的进展,并围绕颅内动脉斑块特征与卒中发生与复发的关系、斑块特征与卒中机制的关系等方面进行探讨,以期为ICAS相关缺血性卒中的诊疗提供依据。Intracranial atherosclerosis(ICAS)is the main cause of ischemic stroke in the world.In clinical practice,ICAS is mainly identified through imaging examinations.In recent years,high-resolution magnetic resonance vessel wall imaging(HRMR-VWI)has gradually become an important means for evaluating the characteristics of ICAS plaques.The application of HRMR-VWI has increased the accuracy in identifying the pathogenesis of acute ischemic stroke,providing a reference for the secondary prevention and clinical individualized treatment of stroke.This article systematically reviews the imaging manifestations of the main components of ICAS plaques on HRMR-VWI,summarizes the progress on HRMR technology,and discusses the relationship between intracranial arterial plaque characteristics and stroke occurrence and recurrence as well as the relationship between plaque characteristics and stroke mechanisms,aiming to provide a basis for the diagnosis and treatment of ICAS-related ischemic stroke.

关 键 词：缺血性卒中 高分辨率磁共振血管壁成像 动脉粥样硬化 卒中机制 

分 类 号：R743.1[医药卫生—神经病学与精神病学] R741.04[医药卫生—临床医学]