阿托伐他汀联合氯吡格雷治疗后循环脑梗死的临床效果分析  

Analysis of Clinical Effect of Atorvastatin Combined with Clopidogrel in Treatment of Posterior Circulation Cerebral Infarction

作　　者：黄凌云 Huang Lingyun(Department of Neurology,Yiyang Central Hospital in Hunan Province,Yiyang 413009,Hunan Province,China)

机构地区：[1]湖南省益阳市中心医院神经内科,湖南益阳413009

出　　处：《中国社区医师》2025年第5期15-17,共3页Chinese Community Doctors

摘　　要：目的:探究阿托伐他汀联合氯吡格雷治疗后循环脑梗死的临床效果。方法:选取2022年1月—2023年12月湖南省益阳市中心医院神经内科收治的120例后循环脑梗死患者进行研究,根据随机数字表法分为对照组和观察组,各60例。对照组给予阿托伐他汀治疗,观察组在对照组基础上给予氯吡格雷治疗。比较两组斑块面积、不良反应发生情况、肢体功能、神经功能及认知功能。结果:治疗1、3、6个月后,两组斑块面积均缩小,且观察组小于对照组(P<0.05)。两组不良反应总发生率比较,无统计学差异(P>0.05)。治疗后,两组上肢功能、下肢功能评分均高于治疗前,且观察组较对照组高(P<0.05)。治疗后,两组神经功能评分降低,且观察组较对照组低(P<0.05);两组认知功能评分升高,且观察组较对照组高(P<0.05)。结论:阿托伐他汀联合氯吡格雷治疗后循环脑梗死的临床效果较好,可缩小斑块面积,改善患者的肢体功能、认知功能及神经功能,且安全性较高。Objective:To explore the clinical effect of atorvastatin combined with clopidogrel in treatment of posterior circulation cerebral infarction.Methods:From January 2022 to December 2023,120 patients with posterior circulation cerebral infarction admitted to Department of Neurology at Yiyang Central Hospital in Hunan Province were selected for study.They were divided into control group and observation group according to the random number table method,with 60 cases in each group.The control group was treated with atorvastatin,and the observation group was treated with clopidogrel on the basis of control group.The plaque area,occurrence of adverse reactions,limb function,neurological function and cognitive function of the two groups were compared.Results:After 1 month,3 months and 6 months of treatment,the plaque area in the two groups decreased,and this parameter in the observation group was smaller than that in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,the scores of upper limb function and lower limb function in the two groups were higher than those before treatment,and the scores in the observation group were higher than those in the control group(P<0.05).After treatment,the neurological function scores in the two groups decreased and the scores in the observation group were lower than those in the control group(P<0.05).The cognitive function scores in the two groups increased and the scores in the observation group were higher than those in the control group(P<0.05).Conclusion:Atorvastatin combined with clopidogrel has a good clinical effect in the treatment of posterior circulation cerebral infarction,and can reduce the plaque area,improve the limb function,cognitive function and neurological function of patients,and has a high safety profile.

关 键 词：阿托伐他汀 氯吡格雷 后循环脑梗死 肢体功能 神经功能 认知功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]