四物五子汤治疗湿性年龄相关性黄斑变性对血管内皮生长因子、转化生长因子-β1及炎性因子水平的影响  

Effect of Siwu Wuzi Decoction on vascular endothelial growth factor,transforming growth factor-β1 and inflammatory factor levels in patients with wet age-related macular degeneration

作　　者：马恺悦 张淑 黄世欣 李晓波 MA Kaiyue;ZHANG Shu;HUANG Shixin;LI Xiaobo(School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing,102488;Medical Affair Department,Beijing Emergency Medical Center,Beijing,100031;Medical Affair Department,Eye Hospital of China Academy of Chinese Medical Sciences,Beijing,100040;Hospital Infection Department,Eye Hospital of China Academy of Chinese Medical Sciences,Beijing,100040)

机构地区：[1]北京中医药大学中药学院,北京102488 [2]北京急救中心医务科,北京100031 [3]中国中医科学院眼科医院医务处,北京100040 [4]中国中医科学院眼科医院院感处,北京100040

出　　处：《实用临床医药杂志》2025年第4期6-10,共5页Journal of Clinical Medicine in Practice

基　　金：中国中医科学院眼科医院高水平中医医院课题项目(GSP5-61)。

摘　　要：目的探讨四物五子汤治疗湿性年龄相关性黄斑变性(wAMD)对患者血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)及炎性因子水平的影响。方法将216例wAMD患者随机分成西医组(n=108)与中西医组(n=108)。西医组接受康柏西普+光动力疗法(PDT)治疗,中西医组接受康柏西普+PDT+四物五子汤治疗,2组均治疗3个月。观察2组中医证候积分、最佳矫正视力(BCVA)、眼压、VEGF、TGF-β1、炎性因子水平[白细胞介素(IL)-6、IL-13]、生活质量[低视力者生活质量量表(CLVQOL)]以及临床疗效。结果治疗后,2组中医证候积分均降低,且中西医组中医证候积分低于西医组,差异有统计学意义(P<0.05)。治疗后,2组BCVA均降低,且中西医组BCVA低于西医组,差异有统计学意义(P<0.05)。治疗后,2组眼压均升高,但中西医组眼压低于西医组,差异有统计学意义(P<0.05)。治疗后,2组VEGF、TGF-β1水平均降低,且中西医组VEGF、TGF-β1水平低于西医组,差异有统计学意义(P<0.05)。治疗后,2组IL-6、IL-13水平均降低,且中西医组IL-6、IL-13水平低于西医组,差异有统计学意义(P<0.05)。治疗后,2组CLVQOL评分均升高,且中西医组CLVQOL评分高于西医组,差异有统计学意义(P<0.05)。中西医组治疗总有效率为97.22%,高于西医组的85.19%,差异有统计学意义(P<0.05)。结论四物五子汤治疗wAMD的效果较好,可减轻患者症状,恢复视力,降低眼压,调节VEGF、TGF-β1及炎性因子水平,提高生活质量。Objective To investigate the effect of Siwu Wuzi Decoction in the treatment of wet age-related macular degeneration(wAMD)on the levels of vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),and inflammatory factors in patients.Methods A total of 216 patients with wAMD were randomly divided into western medicine group(n=108)and integrated Chinese and western medicine group(n=108).The western medicine group received conbercept plus photodynamic therapy(PDT),while the integrated Chinese and western medicine group received conbercept,PDT,and Siwu Wuzi Decoction.Both groups were treated for 3 months.The traditional Chinese medicine syndrome scores,best-corrected visual acuity(BCVA),intraocular pressure,VEGF,TGF-β1,inflammatory factor levels[interleukin(IL)-6,IL-13],quality of life[Chinese Low Vision Quality of Life Scale(CLVQOL)],and clinical efficacy were observed in both groups.Results After treatment,the traditional Chinese medicine syndrome scores decreased in both groups,with the scores in the integrated Chinese and western medicine group being lower than those in the western medicine group(P<0.05).After treatment,BCVA decreased in both groups,with the BCVA in the integrated Chinese and western medicine group being lower than that in the western medicine group(P<0.05).After treatment,intraocular pressure increased in both groups,but the intraocular pressure in the integrated Chinese and western medicine group was lower than that in the western medicine group(P<0.05).After treatment,VEGF and TGF-β1 levels decreased in both groups,with the levels in the integrated Chinese and western medicine group being lower than those in the western medicine group(P<0.05).After treatment,IL-6 and IL-13 levels decreased in both groups,with the levels in the integrated Chinese and western medicine group being lower than those in the western medicine group(P<0.05).After treatment,CLVQOL scores increased in both groups,with the scores in the integrated Chinese and western medicine group being higher th

关 键 词：四物五子汤 康柏西普 光动力疗法 湿性年龄相关性黄斑变性 血管内皮生长因子 转化生长因子-Β1 炎性因子 

分 类 号：R774.5[医药卫生—眼科] R285.5[医药卫生—临床医学] R242