Phototherapy:progress,challenges,and opportunities  

作　　者：Xi Yuan Jun-Liang Zhou Lin Yuan Jiangli Fan Juyoung Yoon Xiao-Bing Zhang Xiaojun Peng Weihong Tan 

机构地区：[1]Department of Laboratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [2]Molecular Science and Biomedicine Laboratory(MBL),State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Aptamer Engineering Center of Hunan Province,Hunan University,Changsha 410082,China [3]State Key Laboratory of Fine Chemicals,Frontier Science Center for Smart Materials,Dalian University of Technology,Dalian 116024,China [4]Department of Chemistry and Nanoscience,Ewha Womans University,Seoul 03760,Republic of Korea [5]Wuhan University Shenzhen Research Institute,Shenzhen 518057,China

出　　处：《Science China Chemistry》2025年第3期826-865,共40页中国科学(化学英文版)

基　　金：supported by the National Natural Science Foundation of China (22234003,22325401,22074036,22404128);the Program of Excellent Doctor of Zhongnan Hospital of Wuhan University (ZNYB2022009);the Zhongnan Hospital of Wuhan University Science,Technology and Innovation Seed Fund (CXPY2023027);the Guangdong Basic and Applied Basic Research Foundation (2023A1515110867);the National Research Foundation of Korea for the grant funded by the Korean government (MSIT) (2022R1A2C3005420)。

摘　　要：Phototherapy has emerged as a promising modality in modern medicine,attracting significant attention due to its non-invasiveness,exceptional spatiotemporal controllability,and reduced side effects.Advanced technologies have been developed in phototherapy,encompassing three main approaches:photodynamic therapy,photothermal therapy,and photoactivatable prodrug-based therapy.In this review,we present photosensitizers,photothermal agents,and photoactivatable prodrugs,along with photo-responsive carriers used in therapy.Subsequently,we discuss the advantages of phototherapy in combating cancer,infections,and other diseases.Additionally,we highlight the benefits of combining phototherapy with other treatments,as single-mode therapeutic modalities often fail to achieve satisfactory efficiency.Finally,we address the current challenges in developing effective phototherapy agents,particularly regarding their clinical applications.We believe that advancements in phototherapy will promote non-invasive theranostic techniques for clinical studies.

关 键 词：PHOTOTHERAPY photo-activation NON-INVASIVE spatial accuracy biomedical applications 

分 类 号：R454.2[医药卫生—治疗学]