含硼荧光材料及其在硼中子俘获治疗中的应用  

Boron-containing Fluorescent Materials and Their Application in Boron Neutron Capture Therapy

作　　者：庞淼 钟天源 潘勇 齐延新 黄宇彬 PANG Miao;ZHONG Tianyuan;PAN Yong;QI Yanxin;HUANG Yubin(Department of Chemistry,Northeast Normal University,Changchun 130024,China)

机构地区：[1]东北师范大学化学学院,长春130024

出　　处：《材料导报》2025年第5期91-96,共6页Materials Reports

基　　金：国家自然科学基金面上项目(52273124);深圳市科技计划资助(JCYJ20230807112801003);中央高校基本科研业务费-青年教师启动基金(2412023QD017)。

摘　　要：硼中子俘获治疗(Boron neutron capture therapy,BNCT)作为一种二元靶向放射疗法,已经显示出强大的抗癌潜力。该治疗方法对肿瘤细胞具有高选择性和杀伤力,其有效性主要取决于足够浓度的^(10)B在肿瘤中积累。在BNCT过程中实时观察硼的组织分布和代谢情况一直是治疗过程中的挑战。荧光成像作为一种潜在的灵敏光谱技术,是用于评估组织中的硼分布的可靠选择。因此,将BNCT与荧光成像相结合的研究引起人们的广泛关注。本文重点介绍了含硼荧光材料的种类及应用,并对其中应用在BNCT中的荧光材料进行了详细介绍。进一步讨论了这些含硼材料在BNCT中的技术瓶颈以及可能的解决途径。最后,对BNCT中含硼荧光材料的可行设计和应用前景进行了展望,为含硼荧光材料的设计提供了新的指导。Boron neutron capture therapy(BNCT),as a binary targeted radiotherapy,has shown strong anti-cancer potential.This treatment is highly selective and lethal to tumor cells,and its effectiveness mainly depends on the accumulation of sufficient concentrations of^(10)B in the tumor.Real-time observation of boron’s tissue distribution and metabolism during the BNCT process has always been a challenge in the treatment.Fluo-rescence imaging,as a potential sensitive spectral technique,is a reliable choice for evaluating boron distribution in tissues.Therefore,research combining BNCT with fluorescence imaging has attracted widespread attention.In this review,we focus on the types and applications of boron-containing fluorescent materials and provide a detailed introduction to the fluorescent materials applied in BNCT.Further,we discuss the technical bottlenecks of these boron-containing materials in BNCT and possible solutions.Finally,we look forward to the feasible design and application prospects of boron-containing fluorescent materials in BNCT,providing new guidance for the design of boron-containing fluorescent materials.

关 键 词：硼中子俘获治疗 成像 荧光分子 多孔材料 

分 类 号：R914.2[医药卫生—药物化学]