Profiling the cell diversity and tissue structure of aqueous humor circulatory system in human eyes using spatial single-cell RNA sequencing  

作　　者：Hao Yuan Zhaona Song Xiao Sun Chunping Song Lidong Guo Qiang Zhang Yonglun Luo Chengfu Yuan Jianlu Gao Xiaodong Jia 

机构地区：[1]Joint Laboratory for Translational Medicine Research,Liaocheng People's Hospital,Liaocheng,Shandong 252000,China [2]College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Ophthalmology,Liaocheng People's Hospital,Liaocheng,Shandong 252000,China [4]Lars Bolund Institute of Regenerative Medicine,Qingdao-Europe Advanced Institute for Life Sciences,BGI-Qingdao,BGI-Shenzhen,Qingdao,Shandong 266555,China [5]Department of Biomedicine,Aarhus University,Aarhus 8000,Denmark [6]Liaocheng People's Hospital,Shandong University,Liaocheng,Shandong 252000,China [7]College of Basic Medical Science,China Three Gorges University,Yichang,Hubei 443002,China

出　　处：《Genes & Diseases》2025年第1期56-59,共4页基因与疾病(英文)

基　　金：supported by grants from the Natural Science Foundation of Shandong Province,China(No.ZR2019QH009).

摘　　要：Elevated intraocular pressure(IOP)is recognized as a significant contributor to the development of various ocular diseases,especially glaucoma.The delicate balance between the generation and drainage of aqueous humor(AH)in the anterior chamber angle regulates the real lop level.Despite extensive research,our understanding of the cellular components,tissue structure,and functional heterogeneity within the AH circulatory system(AHCS)remains incomplete,hindering the progression of effective and accessible treatment strategies for Iop intervention.Therefore,the state-of-the-art spatiotemporal single-cell omics stands poised to furnish an invaluable spatial cellular map of the AHCS,thereby laying the foundation for subsequent in-depth investigations.Meanwhile,this innovative approach promises to offer novel insights into the pathogenesis and management of IOP regulation.

关 键 词：structure thereby INCOMPLETE 

分 类 号：R773.9[医药卫生—眼科]