Heterozygous deletion of Cul4b in female mice leads to ovulatory dysfunction and female infertility  

作　　者：Yufeng Wang Yuting Liu Wei Jiang Yu Song Yongxin Zou Molin Wang Qiao Liu Gongping Sun Yaoqin Gong Baichun Jiang 

机构地区：[1]The Key Laboratory of Experimental Teratology of the Ministry of Education and Department of Genetics,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China [2]The Key Laboratory of Experimental Teratology of the Ministry of Education and Department of Histology and Embryology,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China

出　　处：《Genes & Diseases》2025年第1期122-125,共4页基因与疾病(英文)

基　　金：supported by the National Natural Science Foundation of China(No.31970559,82171851,32370652).

摘　　要：It is estimated that infertility impacts 8%-12%of reproductive-aged couples worldwide.Female infertility accounts for 37%of causes among infertile couples,and ovulatory dysfunction is regarded as its most common factor.1 cUL4B belongs to the Cullin family,whose members are the scaffolding proteins of Cullin-RING E3 ligases(CRLs).Human CUL4B gene mutations result in X-linked mental retardation syndromes.In addition to mental retardation,patients have symptoms such as short stature,obesity,and hypogonadism.

关 键 词：INFERTILITY FEMALE DYSFUNCTION 

分 类 号：Q322[生物学—遗传学]