Integrating single-cell RNA sequencing and bulk RNA sequencing data to predict acute respiratory distress syndrome in sepsis patients  

作　　者：Miao Wang Xiaoer Jin Qingbo Liao Yufan Pu Xiaowen Xu Xiaoqiang Ren Gaoqing Liu Zhiwei Zhuang Qi Ding 

机构地区：[1]The Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou,Jiangsu 215000,China [2]Gusu School,Nanjing Medical University,Suzhou,Jiangsu 215000,China [3]Department of Emergency,Suzhou Municipal Hospital,Suzhou,Jiangsu 215000,China [4]First Affiliated Hospital of Suzhou University,Suzhou,Jiangsu 215000,China

出　　处：《Genes & Diseases》2025年第1期155-157,共3页基因与疾病(英文)

基　　金：supported by the Gusu Talent Project of Suzhou Health Commission(Jiangsu,China)(No.GSWS2020065).

摘　　要：Sepsis affects approximately 20%-30%of patients admitted to the intensive care unit.i Acute respiratory distress syndrome(ARDS)is recognized as one of the earliest and most common complications of sepsis,occurring when sepsis triggers a systemic infection and provokes an uncontrolled inflammatory response that can lead to severe lung damage.2 Studies have demonstrated that patients with sepsisinduced ARDS face not only a mortality risk ranging from 30%to 40%3 but also long-term outcomes such as cognitive impairment and memory loss.4 Moreover,patients with sepsis-associated ARDs have a higher'mortality rate compared with those with ARDS caused by other factors and tend to have suboptimal treatment outcomes once ARDs develops.5 Therefore,early identification and treatment initiation are crucial to prevent ARDS in sepsis,reduce mortality,and minimize healthcare costs.

关 键 词：SEPSIS PATIENTS DISTRESS 

分 类 号：R56[医药卫生—呼吸系统]