Extrachromosomal circular DNA and their roles in cancer progression  

作　　者：Siqi Zheng Yunong Li Lin Wang Qian Wei Minjie Wei Tao Yu Lin Zhao 

机构地区：[1]Department of Pharmacology,School of Pharmacy,China Liaoning Key Laboratory of Molecular Targeted Anti-Tumor Drug Development and Evaluation,Liaoning Cancer Immune Peptide Drug Engineering Technology Research Center,Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors,Ministry of Education,China Medical University,Shenyang,Liaoning 110122,China [2]Department of Medical Imaging,Cancer Hospital of China Medical University,Liaoning Cancer Hospital&Institute,Shenyang,Liaoning 110042,China

出　　处：《Genes & Diseases》2025年第1期209-223,共15页基因与疾病(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(No.82073281,8157346282073884,U20A20413);Shenyang S&T Projects(Liaoning,China)(No.20-204-4-22);Science and Technology Innovation Team Project of China Medical University(No.CXTD2022007);Supporting the High-Quality Development of Science and Technology Funding Projects at China Medical University(No.2022011963-JH2/202).

摘　　要：Extrachromosomal circular DNA(eccDNA),a chromosome-independent circular DNA,has garnered significant attention due to its widespread distribution and intricate biogenesis in carcinoma.Existing research findings propose that multiple eccDNAs contribute to drug resistance in cancer treatments through complex and interrelated regulatory mechanisms.The unique structure and genetic properties of eccDNA increase tumor heterogeneity.This increased diversity is a result of eccDNA’s ability to stimulate oncogene remodeling and participate in anomalous splicing processes through chimeric cyclization and the reintegration of loop DNA back into the linear genome.Such actions promote oncogene amplification and silencing.eccDNA orchestrates protein interactions and modulates protein degradation by acting as a regulatory messenger.Moreover,it plays a pivotal role in modeling the tumor microenvironment and intensifying the stemness characteristics of tumor cells.This review presented detailed information about the biogenesis,distinguishing features,and functions of eccDNA,emphasized the role and mechanisms of eccDNA during cancer treatment,and further proposed the great potential of eccDNA in inspiring novel strategies for precision cancer therapy and facilitating the discovery of prognostic biomarkers for cancer.

关 键 词：Alternative splicing Cancer stem cell Extrachromosomal circle DNA Protein-protein interaction Tumor heterogeneity Tumor immune microenvironment 

分 类 号：R730.2[医药卫生—肿瘤]