钇^(90)微球在结直肠癌肝转移治疗中的应用  

Clinical application of yttrium-90 microspheres in the treatment of hepatic metastases from colorectal cancer

作　　者：朱晓阳 邵国良[2] ZHU Xiaoyang;SHAO Guoliang(Second College of Clinical Medicine,Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang Province 310053,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江省肿瘤医院放射科

出　　处：《介入放射学杂志》2025年第1期115-120,共6页Journal of Interventional Radiology

摘　　要：肝脏是结直肠癌最常见的转移部位,治疗相对困难。目前钇^(90)微球选择性内放疗(selective internal radiotherapy,SIRT)治疗结直肠癌肝转移(colorectal cancer liver metastasis,CRLM)在国内已进入临床应用。这种新型内放射治疗虽有其技术难点,但与传统治疗相比也具有独特优势。其可有效控制肿瘤进展,并为暂时无法手术切除肿瘤患者增加未来残余肝体积(future liver remnant,FLR),从而达到R0切除或理想的放射消融创造条件。其联合一、二线化疗可改善肝转移瘤局部区域反应,为患者提供化疗间期。对于化疗失败且肿瘤不可切除患者,SIRT可更好地控制肿瘤进展、延长患者生存期。未来联合靶向治疗和免疫治疗也有广阔的发展前景。该文主要就钇^(90)微球及其在CRLM中的应用和进展作一综述。The liver is the most common site of metastases from colorectal cancer, and its treatment is relatively difficult.Nowadays in China, selective internal radiotherapy(SIRT) with yttrium-90 microspheres for colorectal cancer liver metastasis(CRLM) has been employed in clinical practice.Although it has technical difficulties, this novel therapeutic mode of internal radiation therapy carries some unique advantages when compared with the traditional therapy.SIRT with yttrium-90 microspheres can effectively control the tumor progression and increase the volume of future liver remnant(FLR) for patients who are temporarily unable to receive surgical resection of the tumor, thus it can create conditions for subsequent R0 resection or radiation ablation.Combined with first-line and second-line chemotherapy, SIRT with yttrium-90 microspheres can improve the local regional response of liver metastases, thus providing patients with sufficient chemotherapy intervals.For patients whose chemotherapy failed and whose tumor is unresectable, SIRT with yttrium-90 microspheres can better control the tumor progression and prolong the survival of patients.SIRT with yttrium-90 microspheres combined with targeted therapy and immunotherapy also has broad application prospects.This paper aims to make a comprehensive review about the application and recent progress of yttrium-90 microspheres in treating CRLM.

关 键 词：钇^(90) 微球 结直肠癌肝转移 选择性内放疗 

分 类 号：R735.7[医药卫生—肿瘤]