帕金森病脑深部电刺激术治疗进展  

Progress of deep brain stimulation for Parkinson's disease

作　　者：白宇彤 杨岸超[1,2] 张建国 BAI Yu-tong;YANG An-chao;ZHANG Jian-guo(Center of Neurosurgery,Beijing Tiantan Hospital,Beijing Neurosurgical Institute,Beijing Key Laboratory of Neurostimulation,Capital Medical University,Beijing 100070,China;National Engineering Research Center for Neuromodulation,Beijing 100084,China)

机构地区：[1]首都医科大学附属北京天坛医院神经外科学中心、首都医科大学北京市神经外科研究所、神经电刺激研究与治疗北京市重点实验室,100070 [2]神经调控国家工程研究中心,北京100084

出　　处：《中国现代神经疾病杂志》2025年第1期17-23,共7页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(项目编号:82402252);国家自然科学基金资助项目(项目编号:82371267)。

摘　　要：脑深部电刺激术作为一种成熟的神经调控技术,广泛应用于多种神经精神疾病的治疗,帕金森病是其最早应用的适应证之一,在多个领域取得令人瞩目的进展。本文以帕金森病脑深部电刺激术优化为主线,聚焦手术技术革新与神经回路机制研究两大方向,分别探讨脑深部电刺激术的手术技术创新、硬件设备优化、程控策略改进、神经回路标志物识别与应用,不仅显著提高疗效,而且为神经调控技术的未来发展提供宝贵思路和科学依据。As a mature neuromodulation technique,deep brain stimulation(DBS)has been widely used in the treatment of various neurological and psychiatric disorders.Parkinson's disease(PD)is one of the earliest indications for DBS and has received the most treatment so far.It has attracted extensive attention and in-depth research from the academic community for a long time,and has made remarkable progress in multiple fields.This review highlights the optimization of DBS for PD,focusing on two key directions:surgical technology innovation and neural circuit mechanism research.It explores the surgical technology innovation,equipment innovation,and programming strategy improvement of DBS,as well as the recognition and application of neural circuit markers.These studies not only significantly improve the efficacy of PD treatment,but also provide valuable ideas and scientific basis for the future development of neuromodulation technique.

关 键 词：帕金森病 深部脑刺激法 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]