特发性震颤神经调控治疗进展  

Progress on neuromodulation for treatment of essential tremor

作　　者：郭松[1] 张弘灏 李建宇[1] 杨岸超[2,3,4] GUO Song;ZHANGHong-hao;LI Jian-yu;YANG An-chao(Department of Functional Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Center of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China;Beijing Neurosurgical Institute,Beijing Key Laboratory of Neurostimulation,Capital Medical University,Beijing 100070,China;National Engineering Research Center for Neuromodulation,Beijing 100084,China)

机构地区：[1]首都医科大学宣武医院功能神经外科,北京100053 [2]首都医科大学附属北京天坛医院神经外科学中心,100070 [3]首都医科大学北京市神经外科研究所、神经电刺激研究与治疗北京市重点实验室,100070 [4]神经调控国家工程研究中心,北京100084

出　　处：《中国现代神经疾病杂志》2025年第1期24-32,共9页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金资助项目(项目编号:82371267);国家重点研发计划项目(项目编号:2021YFC2400204)。

摘　　要：特发性震颤是临床常见的运动障碍疾病,对于部分震颤症状严重、日常生活活动受到影响且药物疗效欠佳的患者可予以神经调控治疗,其疗效优于药物治疗。本文拟对特发性震颤的神经调控治疗最新进展进行综述,包括磁共振引导下聚焦超声、方向性电极和可感知脑深部电刺激术以及脑深部电刺激术最佳刺激靶点的临床研究,以为特发性震颤的治疗提供参考。Essential tremor(ET)is the most common movement disorder in clinical practice.Some patients'daily activities are affected because of the serious tremor.The current drug treatment for this disease is not effective,but the neuromodulation technique such as deep brain stimulation(DBS)is effective.This article provides a review of the latest developments in neuromodulation for the treatment of ET,including clinical trails on magnetic resonance-guided focused ultrasound(MRgFUS),directional-DBS and percept-DBS,as well as the optimal stimulation targets for DBS,in order to provide a reference for the treatment of ET.

关 键 词：特发性震颤 磁共振成像 超声疗法 深部脑刺激法 综述 

分 类 号：R742.5[医药卫生—神经病学与精神病学]