罕见运动障碍疾病神经调控治疗进展  

Progress on neuromodulation for treatment of rare movement disorders

作　　者：董文文 邱畅 徐怿琛 杨岸超[2,3] 章文斌 DONG Wen-wen;QIU Chang;XU Yi-chen;YANG An-chao;ZHANG Wen-bin(Department of Functional Neurosurgery,The Affiliated Brain Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu,China;Center of Neurosurgery,Beijing Tiantan Hospital,Beijing Neurosurgical Institute,Beijing Key Laboratory of Neurostimulation,Capital Medical University,Beijing 100070,China;National Engineering Research Center for Neuromodulation,Beijing 100084,China)

机构地区：[1]南京医科大学附属脑科医院功能神经外科,210029 [2]首都医科大学附属北京天坛医院神经外科学中心、首都医科大学北京市神经外科研究所、神经电刺激研究与治疗北京市重点实验室,100070 [3]神经调控国家工程研究中心,北京100084

出　　处：《中国现代神经疾病杂志》2025年第1期41-47,共7页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：江苏省重点研发计划产业前瞻与关键技术研发项目(项目编号:BE2022049);江苏省重点研发计划产业前瞻与关键技术研发项目(项目编号:BE2022049-1)。

摘　　要：罕见运动障碍疾病的传统药物治疗效果有限,而脑深部电刺激术、脊髓电刺激术,以及经颅磁刺激、经颅直流电刺激和电休克疗法等神经调控技术的兴起为罕见运动障碍疾病的治疗带来新的希望。本文系统回顾并总结上述侵入性和非侵入性神经调控技术在脊髓小脑性共济失调、亨廷顿病、神经棘红细胞增多症等多种罕见运动障碍疾病中的应用及疗效,以为神经调控技术在罕见运动障碍疾病中的应用提供指导。Traditional pharmacological treatments for rare movement disorders have limited efficacy.However,the emergence of neuromodulation technique such as deep brain stimulation(DBS),spinal cord stimulation(SCS),transcranial magnetic stimulation(TMS),transcranial direct current stimulation(tDCS)and electroconvulsive therapy(ECT)offers new hope for patients with rare movement disorders.This review systematically summarizes the application and efficacy of both invasived and non-invasived neuromodulation techniques in treating various rare movement disorders,including spinocerebellar ataxia(SCA),Huntington's disease(HD),and neuroacanthocytosis(NA),etc..The aim is to provide guidance for the application of neuromodulation technique in rare movement disorders.

关 键 词：动作障碍 电刺激疗法 物理刺激 经颅磁刺激 综述 

分 类 号：R741[医药卫生—神经病学与精神病学]