血清中亚硝酸盐含量与鼻咽癌的关系  

The Association Between Serum Nitrite Content and Nasopharyngeal Carcinoma

作　　者：许燕玲 李晶[2] 叶青[2] 王晓燕[2] 蒋诗瑶 许鸿修 XU Yanling;LI Jing;YE Qing;WANG Xiaoyan;JIANG Shiyao;XU Hongxiu(Department of Otolaryngology,Quanzhou Women's and Children's Hospital,Quanzhou Fujian 362000,China;Department of Otolaryngology,Fujian Provincial Hospital/Provincial Clinical College of Fujian Medical University,Fuzhou Fujian 350001,China)

机构地区：[1]泉州市妇幼保健院·儿童医院耳鼻喉科,福建泉州362000 [2]福建省立医院/福建医科大学省立临床医学院耳鼻咽喉科,福建福州350001

出　　处：《中国卫生标准管理》2025年第2期114-117,共4页China Health Standard Management

摘　　要：目的探讨血清中亚硝酸盐含量与鼻咽癌的关系,以及其在鼻咽癌发生和发展中可能存在的作用。方法选取2020年5月—2021年5月在福建省立医院耳鼻喉科确诊的56例鼻咽癌患者为试验组,并选取同期在福建省立医院体检的60名正常者作为对照组。采用改良Griess法检测血清中的亚硝酸盐浓度,比较试验组与对照组血清亚硝酸盐浓度,并分析试验组不同性别、鼻咽癌病理分型、有无淋巴结转移、不同分期下血清亚硝酸盐浓度。结果试验组血清亚硝酸盐浓度为11.99(7.67,12.33)mg/L,高于对照组的1.20(0.54,1.65)mg/L,差异有统计学意义(P<0.05)。试验组有淋巴结转移患者血清亚硝酸盐浓度为16.03(8.98,19.39)mg/L,高于无淋巴结转移患者的7.47(7.30,8.50)mg/L,差异有统计学意义(P<0.05)。试验组不同分期患者血清中亚硝酸盐浓度比较差异有统计学意义(P<0.05)。结论鼻咽癌患者的外周血清亚硝酸盐浓度高于正常者,且伴有淋巴结转移的患者浓度更高,这提示亚硝酸盐在鼻咽癌的发生、发展及转移中具有重要作用。Objective To investigate the relationship between serum nitrite content and nasopharyngeal carcinoma and its possible role in the occurrence and development of nasopharyngeal carcinoma.Methods A total of 56 patients with nasopharyngeal carcinoma diagnosed in the department of otolaryngology,Fujian Provincial Hospital from May 2020 to May 2021 were selected as the experimental group,and 60 normal subjects who underwent physical examination in Fujian Provincial Hospital during the same period were selected as the control group.The modified Griess method was used to detect the serum nitrite concentration,and the serum nitrite concentration of the experimental group and the control group was compared,and the serum nitrite concentration of the experimental group was analyzed under different genders,pathological types of nasopharyngeal carcinoma,whether there was lymph node metastasis,and different stages.Results The serum nitrite concentration of experimental group was 11.99(7.67,12.33)mg/L,which was higher than 1.20(0.54,1.65)mg/L of control group,and the difference was statistically significant(P<0.05).Serum nitrite concentration in patients with lymph node metastasis in experimental group was 16.03(8.98,19.39)mg/L,which was higher than 7.47(7.30,8.50)mg/L in patients without lymph node metastasis,and the difference was statistically significant(P<0.05).There were significant differences in serum nitrite concentration among different stages of experimental group(P<0.05).Conclusion The concentration of nitrite in peripheral blood of patients with nasopharyngeal carcinoma is higher than that of normal patients,and the concentration of patients with lymph node metastasis is higher,suggesting that nitrite plays an important role in the occurrence,development and metastasis of nasopharyngeal carcinoma.

关 键 词：鼻咽癌 转移 亚硝酸盐 淋巴结 性别 病理 

分 类 号：R739[医药卫生—肿瘤]