青少年癫痫共病焦虑抑郁患者的睡眠特点研究及相关性分析  

Study on sleep characteristics of adolescent epileptic patients with comorbid anxiety and depression

作　　者：刘文超 张开慧 徐小莲 耿建红[2] 祝新莉[1] LIU Wenchao;ZHANG Kaihui;XU Xiaolian(Department of Electrophysiology,the Affiliated Hospital of Weifang Medical University,Weifang(261041),Shangdong,China)

机构地区：[1]潍坊医学院附属医院电生理室,山东潍坊261041 [2]潍坊医学院附属医院神经内二科,山东潍坊261041

出　　处：《癫痫与神经电生理学杂志》2025年第1期27-32,共6页Journal of Epileptology and Electroneurophysiology

基　　金：山东省学校卫生协会心理健康与精神卫生研究专项课题(XLZX2024050)。

摘　　要：目的探讨青少年癫痫共病焦虑抑郁患者的睡眠特点,分析癫痫、焦虑抑郁与睡眠障碍的相关性。方法纳入潍坊医学院附属医院2022年7月至2024年6月行长程视频脑电图监测确诊的65例青少年癫痫患者为研究对象,每例患者均进行癫痫抑郁量表(NDDI-E)、广泛性焦虑障碍量表(GAD-7)评估,根据评估结果分为青少年癫痫无共病焦虑抑郁组(对照组)和青少年癫痫共病焦虑抑郁组(观察组),两组患者均进行标准多导睡眠监测(PSG),探讨两组患者睡眠障碍的特点,分析癫痫、焦虑抑郁与睡眠障碍的相关性。结果观察组患者睡眠结构与正常值比较睡眠潜伏期延长、总睡眠时间(TST)缩短、睡眠效率降低、微觉醒指数(MAI)增高、N1期和N2期睡眠百分比增多、N3期睡眠百分比减少、REM睡眠潜伏期延长、REM睡眠百分比减少,差异有统计学意义(P<0.05);对照组患者睡眠结构与正常值比较睡眠潜伏期、TST及MAI正常,睡眠效率降低、N1期和N2期睡眠百分比减少、N3期睡眠百分比增多、REM睡眠潜伏期延长、REM睡眠百分比减少,差异有统计学意义(P<0.05)。观察组较对照组睡眠潜伏期延长、TST缩短、睡眠效率降低、MAI增高、N1期和N2期睡眠百分比增多、N3期睡眠百分比减少,差异有统计学意义(P<0.05)。结论青少年癫痫共病焦虑抑郁患者更容易出现睡眠障碍,主要影响睡眠结构及睡眠效率,且癫痫患者更易共病焦虑抑郁及睡眠障碍。Objective To explore sleep characteristics of adolescent epileptic patients with comorbid anxiety and depression,and analyze the associations of epilepsy,anxiety and depression with sleep disorders.Method A total of 65 adolescent epileptic patients with comorbid anxiety and depression diagnosed by long-term video electroencephalogram monitoring were selected as research subjects in the affiliated Hospital of Weifang Medical university from July 2022 to June 2024.Each patient was evaluated using Neurological Disorders Depression Inventory for Epilepsy(NDDI-E)and Generalized Anxiety Disorder-7(GAD-7)scale.According to the evaluation results,the patients were divided into control group(the absence of the comorbidity of epilepsy with anxiety and depression)and observation group(the presence of the comorbidity of epilepsy with anxiety and depression).Polysomnography(PSG)was conducted on two groups pf the patients.The characteristics of sleep disorders was investigated in two groups.Epilepsy,anxiety and depression in relation to sleep disorder were analyzed.Results When compared to normal values,observation group showed the prolonged sleep latency,the shortened total sleep time(TST),the decreased sleep efficiency,the increased micro-arousal index(MAI),increased percentages of sleep in N1 and N2 stages,the decreased percentage of sleep in N3 stage,the prolonged REM sleep latency and the decreased percentage of sleep in REM(P<0.05).Control group had normal sleep latency,total sleep time(TST)and MAI,the decreased sleep efficiency,the decreased percentages of sleep in N1 and N2 stages,the increased percentage of sleep in N3 stage,the prolonged REM sleep latency and the decreased percentage of sleep in REM relative to normal values(P<0.05).Observation group exhibited the prolonged sleep latency,the shortened TST,the decreased sleep efficiency,the increased MAI,the increased percentages of sleep in N1 and N2 stages and the decreased percentage of sleep in N3 stage when compared to control group(P<0.05).Conclusion Adolescent

关 键 词：青少年癫痫 共患病 焦虑抑郁 睡眠障碍 多导睡眠监测 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R749[医药卫生—临床医学]