前白蛋白及中性粒细胞与急性脑梗死患者颅内动脉斑块稳定性的相关性分析  

Correlation analysis of prealbumin and neutrophil with stability of intracranial arterial plaques in patients with acute cerebral infarction

作　　者：王颖辉[1] 付征[1] 远庚[1] 齐文升[1] WANG Yinghui;FU Zheng;YUAN Geng;QI Wensheng(Guanganmen Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 100053,China)

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国实用神经疾病杂志》2025年第4期397-402,共6页Chinese Journal of Practical Nervous Diseases

基　　金：中国中医科学院科技创新工程项目(编号:C12021402911)。

摘　　要：目的分析前白蛋白(PAB)、中性粒细胞与急性脑梗死(ACI)患者颅内动脉斑块稳定性的相关性。方法选取2020-01—2022-12广安门医院治疗的100例ACI患者为观察组,另选取同期广安门医院健康体检者100例为对照组。观察组患者入院后均行高分辨率磁共振颅内动脉管壁成像检查,依据检查结果分为稳定组(n=32)、不稳定组(n=48)及未形成斑块组(n=20)。收集4组对象的PAB及中性粒细胞计数,分析PAB及中性粒细胞与ACI患者颅内动脉斑块稳定性的相关性。结果观察组PAB水平[(260.75±17.53)mg/L]低于对照组[(290.94±16.71)mg/L],中性粒细胞计数[(6.84±1.97)×10^(9)个/L]高于对照组[(5.26±1.34)×10^(9)个/L],差异均有统计学意义(P<0.05)。不稳定组中性粒细胞计数[(7.42±1.67)×10^(9)个/L]高于稳定组[(6.50±2.30)×10^(9)个/L]及未形成斑块组[(5.93±1.63)×10^(9)个/L],PAB水平[(256.15±13.82)mg/L]低于稳定组[(264.98±12.63)mg/L]及未形成斑块组[(279.44±13.65)mg/L],差异均有统计学意义(P<0.05)。经点二列相关性分析证实PAB与颅内动脉斑块稳定性呈负相关(r=-0.653,P<0.05),中性粒细胞计数与颅内斑块稳定性呈正相关(r=0.313,P=0.002)。Logistic回归分析显示,中性粒细胞计数、PAB是ACI患者颅内动脉斑块稳定性的影响因素(P<0.05)。结论ACI患者血清PAB水平降低,中性粒细胞计数升高,PAB及中性粒细胞与ACI患者颅内动脉斑块稳定性存在一定关联性。Objective To analyze the correlation between prealbumin(PAB),neutrophil and the stability of intracranial arterial plaques in patients with acute cerebral infarction(ACI).Methods One hundred ACI patients admitted to Guang’anmen Hospital from January 2020 to December 2022 were selected as the observation group,and 100 healthy individuals who underwent physical examinations in our hospital during the same period were selected as the control group.After admission,patients in the observation group underwent high-resolution magnetic resonance imaging of intracranial arterial wall and were divided into stable group(n=32),unstable group(n=48),and non-plaque group(n=20)based on the examination results.The PAB and neutrophil counts of 4 groups were collected,and the correlation between PAB,neutrophil and the stability of intracranial arterial plaque in ACI patients was analyzed.Results Compared with control group,the PAB level in the observation group was lower(260.75±15.73 vs 290.94±16.71),with a statistical significant difference(P<0.05).Compared with control group,the level of neutrophils in the observation group was higher(6.84±1.97 vs 5.26±1.34),with a statistical significant difference(P<0.05).Compared with stable group and non-plaque group,neutrophil counts in unstable group were higher(7.42±1.67 vs 6.50±2.30 vs 5.93±1.63).The level of PAB was lower than that of stable group and non-plaque group(256.15±13.82 vs 264.98±12.63 vs 279.44±13.65),with a statistical significant difference(P<0.05).PAB was negatively correlated with the stability of intracranial plaques(r=-0.653,P<0.05),and the level of neutrophils was positively correlated with the stability of intracranial plaques(r=0.313,P=0.002)confirmed by point two column correlation.Logistic regression analysis showed that neutrophil count and PAB were influencing factors for the stability of intracranial arterial plaques in ACI patients(P<0.05).Conclusion The serum PAB levels in ACI patients decrease,the neutrophil count in ACI patients increase,and ther

关 键 词：急性脑梗死 颅内动脉斑块 稳定性 前白蛋白 中性粒细胞 

分 类 号：R743.33[医药卫生—神经病学与精神病学]