吡仑帕奈联合丙戊酸钠对部分性发作癫痫患儿脑电图及炎性因子的影响  

Effect of pirampanil combined with valproic acid on EEG and inflammatory factors in children with partial seizure epilepsy

作　　者：马丽媛 马小云 张忠刚 MA Liyuan;MA Xiaoyun;ZHANG Zhonggang(Qinghai Women and Children’s Hospital,Xining 810000,China)

机构地区：[1]青海省妇女儿童医院,青海西宁810000

出　　处：《中国实用神经疾病杂志》2025年第4期443-447,共5页Chinese Journal of Practical Nervous Diseases

基　　金：青海省指导性计划课题(编号:2021-wjzdx-94)。

摘　　要：目的观察吡仑帕奈(PER)联合丙戊酸钠(VPA)治疗部分性发作癫痫患儿的疗效及对脑电图、炎性因子的影响。方法按简单随机法将2021-01—2023-06青海省妇女儿童医院的部分性发作癫痫患儿152例分为2组,各76例。对照组患儿接受丙戊酸钠治疗,观察组患儿接受吡仑帕奈联合丙戊酸钠治疗,2组均治疗5个月。比较2组患儿的临床疗效和治疗前后的脑电图、炎性因子、氧化应激水平及不良反应。结果治疗5个月后观察组总有效率高于对照组(97.37%比85.52%,P<0.05)。治疗5个月后观察组无痫样放电症状、痫样放电幅度下降≥50%者占比均高于对照组(P<0.05),痫样放电幅度下降<50%、痫样放电增加者占比均低于对照组(P<0.05)。治疗5个月后2组IL-1β、IL-4、IL-6水平均低于治疗前,观察组IL-1β、IL-4、IL-6水平低于对照组(P<0.05)。NO、MDA水平方面,治疗5个月后2组相较治疗前均出现下降,观察组相较对照组更低(P<0.05)。观察组不良反应总发生率低于对照组(3.96%比18.42%,P<0.05)。结论吡仑帕奈联合丙戊酸钠治疗部分性发作癫痫患儿,在降低炎性因子、氧化应激水平以及减少痫性放电等方面均展现出良好的效果,不良反应少,安全性高。Objective To observe the efficacy of pirenzepine(PER)combined with valproic acid(VPA)in the treatment of children with partial seizures of epilepsy and its effect on electroencephalogram and inflammatory factors.Methods From January 2021 to June 2023,a total of 152 children with partial seizures of epilepsy admitted to Qinghai Women and Children’s Hospital were randomly divided into two groups.The control group(76 cases)was treated with valproic acid,and the observation group(76 cases)was treated with pirenzepine combined with valproic acid.Both groups were treated for 5 months.The clinical efficacy,electroencephalogram,inflammatory factor indexes,oxidative stress indexes and adverse reactions before and after treatment were compared between the two groups.Results After 5 months of treatment,the total effectiveness in observation group was higher compared with control group(97.37%vs 85.52%,P<0.05).After 5 months of treatment,the proportions of patients without epileptiform discharge symptoms and epileptiform discharge amplitude decreased≥50%in the observation group were higher compared with the control group(P<0.05),while the proportions of patients with epileptiform discharge amplitude decreased<50%and epileptiform discharge increased were lower compared with the control group(P<0.05).After 5 months of treatment,the IL-1β,IL-4 and IL-6 levels in the two groups deceased,and the IL-1β,IL-4 and IL-6 levels in the observation group were lower(P<0.05).After 5 months of treatment,the NO and MDA levels in the two groups deceased,and the NO and MDA levels in the observation group were lower(P<0.05).The total incidence of adverse reactions in the observation group was lower compared with control group(3.96%vs 18.42%,P<0.05).Conclusion The clinical efficacy of pirenzepine combined with valproic acid in the treatment of children with partial seizures of epilepsy is good,and it has good efficacy in reducing the level of inflammatory factors,and the levels of oxidative stress and epileptic discharge,with few adverse re

关 键 词：癫痫 吡仑帕奈 丙戊酸钠 儿童 脑电图 炎性因子 氧化应激 痫样放电 

分 类 号：R742.1[医药卫生—神经病学与精神病学]