脑白质病变与阿尔茨海默病的研究进展  

Research progress of cerebral white matter lesions and Alzheimer’s disease

作　　者：薛清 赵丰丽 XUE Qing;ZHAO Fengli(Graduate School of Changzhi Medical College,Changzhi 046000,China;Yuncheng Hospital Affiliated to Shanxi Medical University,Yuncheng 044000,China)

机构地区：[1]长治医学院研究生院,山西长治046000 [2]山西医科大学附属运城市中心医院,山西运城044000

出　　处：《中国实用神经疾病杂志》2025年第4期508-513,共6页Chinese Journal of Practical Nervous Diseases

基　　金：山西省卫生健康委员会山西省医学重点科技项目(编号:2020XM59);山西省应用基础研究计划项目(编号:201901D211595)。

摘　　要：阿尔茨海默病(AD)是以进行性认知功能减退和行为损害为特征的神经退行性疾病系统,是老年最常见的痴呆类型。以往对AD的研究大多集中在大脑灰质的改变,而对大脑白质的关注较少。随着影像学技术的发展,脑白质微观结构的变化可能成为AD早期生物标志物,预测AD的进展。本文分析了脑白质病变与AD患者认知功能、精神行为和日常生活能力之间的关联,探讨脑白质病变对AD的影响。Alzheimer’s disease(AD),a neurodegenerative disease system characterized by progressive cognitive decline and behavioral impairment,is the most common type of dementia in the elderly.Most previous studies of AD have focused on changes in the gray matter of the brain,with less attention paid to the white matter of the brain.With the development of imaging technology,changes in the microstructure of cerebral white matter may become an early biomarker for AD and predict the progression of AD.This paper analyzed the relationship between cerebral white matter lesions and cognitive function,mental behavior and daily life ability of AD patients,and discussed the impact of cerebral white matter lesions on AD.

关 键 词：阿尔茨海默病 脑白质病变 生物标志物 弥散张量成像 认知障碍 

分 类 号：R742.2[医药卫生—神经病学与精神病学]