高尿酸血症与非酒精性脂肪肝相关性研究进展  

Research Progress on the Correlation Between Hyperuricemia and Nonalcoholic Fatty Liver Disease

作　　者：杜胜兰 贺茜 曾俊 赵卫民 DU Shenglan;HE Qian;ZENG Jun;ZHAO Weimin(Department of Endocrinology,First Clinical Medical College of China Three Gorges University/Yichang Central People′s Hospital,Yichang 443000,Hubei,China;Department of Metabolism and Endocrinology,the Second Xiangya Hospital of Central South University/Hunan Primary Laboratory of Metabolic Osteopathy/National Center for Clinical Medical Research of Metabolic Diseases,Changsha 410011,Hunan,China)

机构地区：[1]三峡大学第一临床医学院/宜昌市中心人民医院内分泌科,湖北宜昌443000 [2]中南大学湘雅二医院代谢内分泌科/代谢性骨病湖南省重点实验室/国家代谢性疾病临床医学研究中心,湖南长沙410011

出　　处：《医学信息》2025年第4期176-181,共6页Journal of Medical Information

基　　金：国家自然科学基金项目(编号:8210021060);宜昌市医疗卫生研究项目(编号:A22-2-027)。

摘　　要：非酒精性脂肪肝的全球流行率不断上升,与生活方式和饮食习惯的改变密切相关。尿酸是一种内源性代谢产物,近年来越来越多的研究表明高尿酸血症与非酒精性脂肪肝之间存在密切的相关性。基于此,本文首先对高尿酸血症与非酒精性脂肪肝相关性展开研究,其次阐述不同体型与性别的高尿酸血症患者发生非酒精性脂肪肝的差异,最后重点总结高尿酸血症导致非酒精性脂肪肝可能的病理分子机制,以期为临床治疗提供参考。The global prevalence of nonalcoholic fatty liver disease is increasing,which is closely related to changes in lifestyle and eating habits.Uric acid is an endogenous metabolite.In recent years,more and more studies have shown that there is a close correlation between hyperuricemia and nonalcoholic fatty liver disease.Based on this,this paper first studies the correlation between hyperuricemia and non-alcoholic fatty liver.Secondly,it expounds the differences in the occurrence of non-alcoholic fatty liver in patients with hyperuricemia of different body types and genders.Finally,it focuses on the possible pathological molecular mechanism of hyperuricemia leading to non-alcoholic fatty liver,in order to provide reference for clinical treatment.

关 键 词：非酒精性脂肪肝 高尿酸血症 代谢性疾病 生物标志物 

分 类 号：R575.5[医药卫生—消化系统]