急性脑梗死患者CD62p Lp-PLA2与早期神经功能恢复的相关性  

Correlation between CD62p,Lp-PLA2 and early recovery of neurological function in patients with acute cerebral infarction

作　　者：刘曙光 赵岩[1] LIU Shuguang;ZHAO Yan(Chifeng Municipal Hospital,Chifeng 024000,China)

机构地区：[1]赤峰市医院,内蒙古赤峰024000

出　　处：《中国实用神经疾病杂志》2025年第3期321-325,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探究血小板P选择素(CD62p)、脂蛋白相关磷脂酶A2(Lp-PLA2)在急性脑梗死患者血清中的表达水平特征及与早期神经功能恢复的相关性。方法选取赤峰市医院2021-02—2023-02就诊的98例急性脑梗死患者,根据患者NIHSS评分变化分为恢复良好组(n=76)和恢复不良组(n=22)。对比2组患者一般临床资料、临床检验指标、血清CD62p及Lp-PLA2表达水平。通过Pearson相关性分析血清CD62p及Lp-PLA2水平与NIHSS、临床检验指标的相关性,采用Logistic回归分析筛选急性脑梗死患者早期神经功能恢复良好的危险因素,血清CD62p、Lp-PLA2水平对急性脑梗死患者早期神经功能恢复良好的诊断效能采用受试者工作特征(ROC)曲线和曲线下面积(AUC)分析。结果恢复不良组患者血清C反应蛋白(CRP)、低密度脂蛋白(LDL)、总胆固醇(TC)显著高于恢复良好组(t=9.204、4.451、6.857,P<0.05),血清CD62p、Lp-PLA2水平均显著高于恢复良好组(t=6.782、13.121,P<0.05)。急性脑梗死患者血清CD62p水平与Lp-PLA2水平呈正相关(r=0.438,P<0.05),CRP、LDL、TC、NIHSS与CD62p呈正相关(r=0.483、0.252、0.328、0.725,P<0.05),CRP、NIHSS与Lp-PLA2呈正相关(r=0.291、0.496,P<0.05)。CD62p及Lp-PLA2均是急性脑梗死患者早期神经功能恢复不良的独立危险因素(P<0.05)。血清CD62p、Lp-PLA2及其联合预测急性脑梗死患者早期神经功能恢复不良的AUC分别为0.651(95%CI:0.539~0.763)、0.742(95%CI:0.639~0.844)、0.750(95%CI:0.649~0.851),其联合诊断的AUC大于CD62p、Lp-PLA2(Z=2.013,P<0.05)。结论急性脑梗死患者血清CD62p及Lp-PLA2表达水平呈正相关,二者对早期神经功能恢复不良均具有一定预测价值。Objective To investigate the expressions of platelet P-selectin(CD62p)and lipoproteinassociated phospholipase A2(Lp-PLA2)in patients with acute cerebral infarction and their correlation with neurological function recovery.Methods Ninety-eight patients with acute cerebral infarction in Chifeng Municipal Hospital from February 2021 to February 2023 were selected as the objects.The neurological damage of the patients in the observation group was evaluated by the NIHSS.According to the changes of NIHSS score,the patients were divided into two groups:good recovery group(n=76)and poor recovery group(n=22).The general clinical data,clinical laboratory parameters,serum CD62p and Lp-PLA2 expression levels were compared between two groups.Pearson correlation analysis was used to evaluate the correlation between serum CD62p and Lp-PLA2 levels and NIHSS,clinical laboratory parameters.Logistic regression analysis was used to screen the risk factors for good early neurological recovery in patients with acute cerebral infarction.The diagnostic efficacy of serum CD62p and Lp-PLA2 levels for good early neurological recovery in patients with acute cerebral infarction was analyzed by receiver operating characteristic(ROC)curves and area under the curve(AUC).Results The average levels of serum C-reactive protein(CRP),low density lipoprotein(LDL)and total cholesterol(TC)in the poor recovery group were significantly higher than those in the good recovery group(t=9.204,4.451,6.857,P<0.05),and the levels of serum CD62p and Lp-PLA2 in the poor recovery group were significantly higher than those in the good recovery group(t=6.782,13.121,P<0.05).There was a positive correlation between the level of serum CD62p and the level of Lp-PLA2 in the patients with acute cerebral infarction(r=0.438,P<0.05).CRP,LDL,TC,NIHSS were positively correlated with CD62p(r=0.483,0.252,0.328,0.725,P<0.05),and CRP,NIHSS were positively correlated with Lp-PLA2(r=0.291,0.496,P<0.05).Both CD62p and Lp-PLA2 were independent risk factors for poor neurological functio

关 键 词：急性脑梗死 血小板P选择素 脂蛋白相关磷脂酶A2 神经功能 危险因素 预测价值 血清 

分 类 号：R743.33[医药卫生—神经病学与精神病学]