种植体表面纳米形貌影响成骨细胞黏附的研究进展  

Progress of research on the effect of implant surface nano-morphology on osteoblast adhesion

作　　者：彭含宇 李潇 PENG Hanyu;LI Xiao(School of Stomatology,Southern Medical University,General Hospital of Southern Theater Command,Guangzhou 510000,China)

机构地区：[1]南方医科大学口腔医学院,广东广州510000 [2]南部战区总医院口腔科,广东广州510000

出　　处：《口腔医学》2025年第2期156-160,共5页Stomatology

基　　金：广州市科技计划项目(202002030095)。

摘　　要：成骨细胞是骨形成的主要功能细胞,它在种植体上的黏附是成骨细胞行使生物学功能的前提。然而临床上常见的种植体大多属于惰性金属,存在生物活性差、缺乏骨诱导等问题,不利于成骨细胞黏附,因此常需要对其进行表面改性。纳米形貌是近年来研究的热点,它具体是指种植体表面单元和尺寸为1~100 nm的拓扑结构,其在结构上与细胞外基质相似,有着亲水性佳、生物相容性好及抗菌等多方面优势,但并非所有的纳米形貌都有利于成骨细胞黏附。本文从成骨细胞在纳米表面的黏附过程、常见纳米表面结构及其表面修饰三个方面进行综述,以期为种植体表面纳米改性和临床应用提供参考。Osteoblasts are the main functional cells of bone formation,and their adhesion to the implants is the premise of biological function.However,most of the common clinical implants are inert metals,which have some problems such as poor biological activity and lack of bone induction,which are not conducive to osteoblast adhesion,so it is often necessary to modify their surface.Nano-morphology is a hot topic in recent years,which refers to the topological structure of implant surface unit and size 1-100 nm,similar to extracellular matrix in structure,with many advantages such as enhanced hydrophilicity,superior biocompatibility and antibacterial properties.However,not all nano-morphologies are conducive to osteoblast adhesion.This paper reviews the adhesion process,common nano-surface structure and surface modification of osteoblasts on nano-surface,in order to provide reference for implant surface nano-modification and clinical application.

关 键 词：种植体 纳米结构 表面改性 成骨细胞 细胞黏附 

分 类 号：R783[医药卫生—口腔医学]