Chitosan:A Scaffold Biomaterial in 3D Bone Tissue Engineering and Its Biological Activities  

壳聚糖:一种应用在三维骨组织工程中的生物活性支架材料

作　　者：Gurung Chetali Nawaz Aamir Udduttulla Anjaneyulu REN Peigen Gurung Chetali;Nawaz Aamir;Udduttulla Anjaneyulu;任培根(中国科学院深圳先进技术研究院能量代谢与生殖研究中心,深圳518055;巴哈瓦尔布尔伊斯兰大学化学研究所无机化学系,巴哈瓦尔布尔63100;韦洛尔科技大学,泰米尔纳德邦韦洛尔632014)

机构地区：[1]Center for Energy Metabolism and Reproduction,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China [2]Institute of Chemistry,Division of Inorganic Chemistry,Islamia University of Bahawalpur,Bahawalpur 63100,Pakistan [3]Vellore Institute of Technology,Vellore,Tamil Nadu 632014,India

出　　处：《集成技术》2025年第2期86-108,共23页Journal of Integration Technology

基　　金：国家重点研发计划项目(2021YFA0719303);国家自然科学基金项目(32271166,32100572);广东省基础与应用基础研究基金项目(2024A1515013017);深圳市科技计划项目(JCYJ20200109115441918,KCXFZ2020122113400002,JCYJ20210324102013035,JCYJ20210324123610028)。

摘　　要：The ability to replicate the microenvironment of the human body through the fabrication of scaffolds is a significant achievement in the biomedical field.However,the search for the ideal scaffold is still in its infancy and there are significant challenges to overcome.In the modern era,the scientific community is increasingly turned to natural substances due to their superior biological ability,lower cost,biodegradability,and lower toxicity than synthetic lab-made products.Chitosan is a well-known polysaccharide that has recently garnered a high amount of attention for its biological activities,especially in 3D bone tissue engineering.Chitosan closely matches the native tissues and thus stands out as a popular candidate for bioprinting.This review focuses on the potential of chitosan-based scaffolds for advancements and the drawbacks in bone treatment.Chitosan-based nanocomposites have exhibited strong mechanical strength,water-trapping ability,cellular interaction,and biodegradability.Chitosan derivatives have also encouraged and provided different routes for treatment and enhanced biological activities.3D tailored bioprinting has opened new doors for designing and manufacturing scaffolds with biological,mechanical,and topographical properties.通过制造支架来模拟人体微环境是生物医学领域的一大成就。然而,寻找理想生物支架的工作仍处于起步阶段,需要克服重大挑战。目前,科学研究更倾向于天然物质,因为它们具有极强的生物能力、低成本和生物可降解性,并且比合成实验室制造的产品毒性更小。壳聚糖是一种著名的多糖,因其生物活性而备受关注,尤其是在3D骨组织工程中。壳聚糖与天然组织非常相似,因此是生物打印的热门候选材料。本文重点分析了基于壳聚糖支架发展的潜力以及骨治疗的缺点。壳聚糖纳米复合材料具有较强的机械强度、吸水能力、细胞相互作用和生物降解特性。壳聚糖衍生物还提供了不同的治疗途径,并且具有较强的生物活性。3D定制生物打印为设计和制造具有生物、机械和地形特性的支架打开了新的大门。

关 键 词：CHITOSAN 3D bioprinting bone tissue engineering SCAFFOLD tissue regeneration chitosan derivative 

分 类 号：Q599[生物学—生物化学]