半夏泻心汤加减治疗寒热错杂型慢性胃炎的应用价值  

Application value of modified Banxia Xiexin decoction in treating chronic gastritis of mixed cold and heat type

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作  者:苏志威 计春燕 孙俊 薛娟 SU Zhiwei;JI Chunyan;SUN Jun;XUE Juan

机构地区:[1]湖北中医药大学,湖北武汉430065 [2]湖北省中西医结合医院,湖北武汉430015

出  处:《中医临床研究》2024年第36期12-15,共4页Clinical Journal Of Chinese Medicine

基  金:湖北省卫生健康委2021-2022年度卫生健康科研项目:Musashi-1和CDX2与慢性萎缩性胃炎伴肠上皮化生的相关性研究(WJ2021F120);2023年湖北省中西医结合医院“杏林人才工程”院级科研重点项目:基于差异表达的lnc RNA SOX21AS1研究胃萎方治疗慢性萎缩性胃炎伴肠上皮化生(瘀热夹杂证)的作用机制(H2023Z005);2023年鄂州市科技计划项目:基于差异表达的lnc RNA SOX21AS1研究胃萎方治疗慢性萎缩性胃炎伴肠上皮化生(瘀热夹杂证)的作用机制(基础研究与人才创新专项)。

摘  要:目的:探讨并观察半夏泻心汤加减治疗寒热错杂型慢性胃炎的应用价值。方法:研究对象选取2022年10月―2023年10月湖北省中西医结合医院收治的慢性胃炎(寒热错杂型)患者86例,按照随机数字表法分为观察组和对照组,每组43例。对照组采用雷贝拉唑钠肠溶胶囊联合阿莫西林胶囊,观察组在对照组的基础上加用半夏泻心汤加减治疗。均治疗4周,对比两组患者治疗前后临床疗效、中医证候积分、C反应蛋白(C-Reactive Protein,CRP)、肿瘤坏死因子(Tumor Necrosis Factor,TNF)-α及胃蛋白酶原(Pepsinogen,PG)情况。结果:治疗前,两组患者中医证候积分、CRP、TNF-α、PG对比,差异不具有统计学意义(P>0.05)。治疗后,两组患者均取得良好疗效,观察组总有效率为97.67%(42/43),对照组总有效率为83.72%(36/43),差异具有统计学意义(P<0.05);治疗后,与对照组相比,观察组中医证候积分CRP、TNF-α炎症指标均下降,PGⅠ、PGⅡ恢复情况均优于对照组,差异均有统计学意义(P<0.05)。结论:半夏泻心汤能明显提高寒热错杂型慢性胃炎患者的临床疗效,降低中医证候积分和CRP、TNF-α炎症指标,改善PG情况,值得进一步研究和探索。Objective:To investigate and observe the application value of modified Banxia Xiexin decoction(半夏泻心汤加减)in treating chronic gastritis of mixed cold and heat type.Methods:The subjects of this study were 86 patients with chronic gastritis(mixed cold and heat type)admitted to Hubei Provincial Hospital of Integrated Chinese and Western Medicine from October 2022 to October 2023,who were divided into the observation group and the control group according to the random number table method,with 43 cases in each group.The control group was treated with Rabeprazole sodium enteric-dissolved capsule combined with amoxicillin capsule.All the patients in the observation group received modified Banxia Xiexin decoction treatment on the basis of the treatment of the control group,and all patients participated in the treatment for 4 weeks.The therapeutic efficacy before and after treatment,TCM symptom score,C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),and necrosis factor-α,and pepsinogen(PG)were compared.Results:There was no significant difference in TCM symptom score,CRP,TNF-αand PG between the two groups before treatment(P>0.05).After treatment,both groups achieved good efficacy,the total effective rate of the observation group was 97.67%(42/43),the total effective rate of the control group was 83.72%(36/43),the difference was statistically significant(P<0.05).After treatment,TCM symptom score of the observation group decreased compared with that of the control group,the difference was statistically significant(P<0.05).After treatment,CRP and TNF-αinflammation indexes in the observation group were decreased compared with those of the control group,and the difference was statistically significant(P<0.05).After treatment,the recovery of PG I and PG II of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Banxia Xiexin decoction can significantly improve the curative effect of patients with chronic gastritis with mixed cold

关 键 词:慢性胃炎 寒热错杂 半夏泻心汤 临床疗效 

分 类 号:R573.3[医药卫生—消化系统]

 

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