佛山地区非肺癌高危人群肺结节筛查的效果分析  

Effect analysis of pulmonary nodule screening in non-lung cancer high-risk groups in Foshan

作　　者：杨沛新 张志海 叶冠伦 张树勋 YANG Peixin;ZHANG Zhihai;YE Gauanlun;ZHANG Shuxun(Health Examination Center,Nanhai Hospital,Guangdong Provincial People's Hospital,Foshan 528251,China;Department of Respiratory Medicine,Nanhai Hospital,Guangdong Provincial People's Hospital,Foshan 528251,China;Department of Radiology,Nanhai Hospital,Guangdong Provincial People's Hospital,Foshan 528251,China)

机构地区：[1]广东省人民医院南海医院健康体检中心,广东佛山528251 [2]广东省人民医院南海医院呼吸内科,广东佛山528251 [3]广东省人民医院南海医院放射科,广东佛山528251

出　　处：《山东第一医科大学(山东省医学科学院)学报》2025年第2期83-88,共6页Journal of Shandong First Medical University & Shandong Academy of Medical Sciences

基　　金：佛山市卫生健康局医学科研课题(20230258)。

摘　　要：目的 探讨佛山地区非肺癌高危人群肺结节筛查的效果,以期为非高危人群肺癌的早筛、早诊提供实践依据。方法 对2023年1月1日至2024年9月30日在广东省人民医院南海医院体检中心体检的佛山地区人员,按照《肺结节诊治中国专家共识(2018年版)》标准,通过问卷调查筛选出非肺癌高危人群,进行胸部低剂量CT(low-dose computed tomography, LDCT)检查,分析肺结节检出率,肺结节与年龄、性别的关系,肺结节的密度、大小、数量等影像学特征。对肺结节患者,除良性结节征象明显者,进行规范随访,获取其临床结局。结果 共筛选出2 731例非肺癌高危人群,其中男性1 181例,女性1 550例。共检出肺结节1 512例,检出率55.36%(1 512/2 731),其中男、女检出率分别为55.04%、55.61%,30~<40岁人群肺结节检出率与≥40岁年龄人群相比,差异无统计学意义(P > 0.05)。检出实性结节829例(30.36%),纯磨玻璃结节660例(24.17%),部分实性结节23例(0.84%),小结节(直径5~≤10 mm)618例(22.63%),> 10 mm肺结节25例(0.92%)。高度疑似肺癌37例,经随诊有11例经病理诊断确诊肺癌,肺癌检出率0.40%,其中早期肺癌(Ι期肺癌)8例,早诊率为72.73%(8/11),均发生于60岁以下患者,2例在30~<40岁间。疑似肺癌和肺癌的检出率随年龄的增长而升高。结论 非肺癌高危人群肺结节筛查可以发现更早期肺癌,提高肺癌早诊率。建议肺结节筛查年龄可提前至30岁,并结合危险因素延长随访时间。Objective:This study investigated the effect of lung nodule screening in non-high-risk groups of lung cancer in Foshan,hoping to provide a practical basis for early screening and early diagnosis of lung cancer in non-high-risk groups.Methods:From January 1,2023 to September 30,2024,those in Foshan who underwent physical examination at the physical examination center of Nanhai hospital of Guangdong Provincial people's hospital were screened out through questionnaires in accordance with the standards of the Chinese expert consensus on the diagnosis and treatment of pulmonary nodules(2018 Edition),and low-dose CT(LDCT)examination of the chest was performed to analyze the detection rate of pulmonary nodules,the relationship between pulmonary nodules and age and gender,and the density,size,and number of pulmonary nodules.For patients with pulmonary nodules,except for those with obvious signs of benign nodules,standardized follow-up was carried out to obtain clinical outcomes.Results:A total of 2731 non-high-risk groups for lung cancer were screened,including 1181 males and 1550 females.A total of 1512 cases of pulmonary nodules were detected,with a detection rate of 55.36%(1512/2731),of which the detection rates of males and females were 55.04%and 55.61%,respectively,and the detection rate of pulmonary nodules in the age group of 30-<40 years was not lower than that of the age group aged 40 years and later,and the detection rate was not related to age,and the difference was not statistically significant(P>0.05).A total of 829 cases(30.36%)of solid nodules,660 cases(24.17%)of pure ground-glass nodules,23 cases(0.84%)of partial solid nodules,618 cases(22.63%)of small nodules(diameter 5~10 mm),and 25 cases(0.92%)of pulmonary nodules larger than 10 mm were detected.There were 37 cases of highly suspected lung cancer,and 11 cases were diagnosed with pathological diagnosis after follow-up,with a detection rate of 0.40%,including 8 cases of early lung cancer(stageΙlung cancer),and the early diagnosis rate was 72.73%(8/11),a

关 键 词：非肺癌高危人群 肺结节 筛查 

分 类 号：R73[医药卫生—肿瘤]