绝经后子宫良性病变伴子宫异常出血患者发生子宫内膜癌的影响因素  

Influencing factors of endometrial cancer in postmenopausal patients with benign uterine lesions and abnormal uterine bleeding

作　　者：冯琳 FENG Lin(Department of Gynecology of Yuanyang County People’s Hospital,Xinxiang 453000 Henan,China)

机构地区：[1]原阳县人民医院妇科,河南新乡453000

出　　处：《中国民康医学》2025年第5期18-20,24,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析绝经后子宫良性病变伴子宫异常出血患者发生子宫内膜癌的影响因素。方法:选取2019—2021年该院收治的200例绝经后子宫良性病变伴子宫异常出血患者进行横断面研究,随访2年,根据是否发生子宫内膜癌将其分为发生组与未发生组。比较两组基线资料,采用Logistic回归分析患者发生子宫内膜癌的影响因素。结果:随访期间,200例绝经后子宫良性病变伴子宫异常出血患者中,60例发生子宫内膜癌,占30.00%(60/200);两组年龄、分娩次数、子宫内膜回声比较,差异均无统计学意义(P>0.05);两组体质量指数(BMI)、绝经年龄、合并糖尿病、子宫内膜厚度、糖类抗原125(CA125)水平、人附睾蛋白4(HE4)水平比较,差异均有统计学意义(P<0.05);Logistic回归分析结果显示,BMI>28 kg/m^(2)、绝经年龄>50岁、合并糖尿病、子宫内膜厚度>10 mm,CA125水平高、HE4水平高均为绝经后子宫良性病变伴子宫异常出血患者发生子宫内膜癌的危险因素(OR>1,P<0.05)。结论:BMI>28 kg/m^(2)、绝经年龄>50岁、合并糖尿病、子宫内膜厚度>10 mm,CA125水平高、HE4水平高均为绝经后子宫良性病变伴子宫异常出血患者发生子宫内膜癌的危险因素。Objective:To analyze influencing factors of endometrial cancer in postmenopausal patients with benign uterine lesions and abnormal uterine bleeding.Methods:A cross-sectional study was conducted on 200 postmenopausal patients with benign uterine lesions and abnormal uterine bleeding admitted to the hospital from 2019 to 2021.These patients were followed up for 2 years.According to whether endometrial cancer occurred,they were divided into the occurrence group and the non-occurrence group.The baseline data were compared between the two groups.Logistic regression was used to analyze the influencing factors of endometrial cancer.Results:During the follow-up period,60 cases of endometrial cancer occurred in the 200 postmenopausal patients benign with uterine lesions and abnormal uterine bleeding,accounting for 30.00%(60/200).There were no significant differences in age,delivery times and endometrial echo between the two groups(P>0.05).There were significant differences in body mass index(BMI),menopausal age,combined diabetes mellitus,endometrial thickness,carbohydrate antigen 125(CA125)level and human epididymis protein 4(HE4) level between the two groups(P<0.05).Logistic regression analysis showed that BMI > 28 kg/m^(2),menopausal age > 50 years old,combined diabetes mellitus,endometrial thickness > 10 mm,high CA125 level and high HE4 level were risk factors for endometrial cancer in the postmenopausal patients with benign uterine lesions and abnormal uterine bleeding(OR>1,P<0.05).Conclusions:BMI > 28 kg/m^(2),menopausal age > 50 years old,combined diabetes mellitus,endometrial thickness > 10 mm,high CA125 level and high HE4 level are the risk factors for endometrial cancer in the postmenopausal patients with benign uterine lesions and abnormal uterine bleeding.

关 键 词：绝经后 子宫良性病变 子宫异常出血 子宫内膜癌 影响因素 

分 类 号：R737.3[医药卫生—肿瘤]