早期血管介入栓塞术治疗颅内动脉瘤破裂患者的效果  

Effects of early vascular interventional embolization in treatment of patients with intracranial aneurysm rupture

作　　者：张奇 郭彦俊 汪宁[1] 孙军[1] ZHANG Qi;GUO Yanjun;WANG Ning;SUN Jun(Second Ward of Department of Neurological Intervention of Nanyang Central Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳市中心医院神经介入科二病区,河南南阳473000

出　　处：《中国民康医学》2025年第5期21-24,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察早期血管介入栓塞术治疗颅内动脉瘤破裂患者的效果。方法:回顾性分析2022年10月至2023年10月该院收治的98例颅内动脉瘤破裂患者的临床资料,根据早期血管介入栓塞术手术时间不同将其分为早期组(n=51)和延期组(n=47)。早期组在发病72 h内进行血管介入栓塞术治疗,延期组在发病72 h后进行血管介入栓塞术治疗。比较两组栓塞成功率,手术前后神经功能缺损程度[美国国立卫生研究院卒中量表(NIHSS)]评分、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、D-二聚体(D-D)]水平、血管内皮因子[血管内皮素-1(ET-1)、一氧化氮(NO)]水平,以及并发症发生率。结果:早期组栓塞成功率为94.12%(48/51),高于对照组的78.72%(37/47),差异有统计学意义(P<0.05);术后2周,两组NIHSS评分均低于术前,且早期组低于延期组,差异有统计学意义(P<0.05);术后2周,两组MDA、D-D水平均低于术前,且早期组低于延期组,两组SOD水平均高于术前,且早期组高于延期组,差异有统计学意义(P<0.05);术后2周,两组ET-1水平均低于术前,且早期组低于延期组,两组NO水平均高于术前,且早期组高于延期组,差异有统计学意义(P<0.05);早期组并发症发生率为5.88%(3/51),低于延期组的21.28%(10/47),差异有统计学意义(P<0.05)。结论:早期血管介入栓塞术治疗颅内动脉瘤破裂患者,可提高栓塞成功率,减轻神经功能缺损程度、氧化应激反应和血管内皮损伤,降低并发症发生率,效果优于延期血管介入栓塞术治疗。Objective:To observe effects of early vascular interventional embolization in treatment of patients with intracranial aneurysm rupture.Methods:The clinical data of 98 patients with intracranial aneurysm rupture admitted to this hospital from October 2022 to October 2023 were retrospectively analyzed.According to the different operation time of early vascular interventional embolization,they were divided into early group(n=51) and delayed group(n=47).The early group was treated with vascular interventional embolization within 72 hours of onset,while the delayed group was treated with vascular interventional embolization after 72 hours of onset.The success rate of embolization,the degree of neurological deficit [National Institutes of Health stroke scale(NIHSS)] scores,the oxidative stress index [superoxide dismutase(SOD),malondialdehyde(MDA),D-dimer(D-D)] levels,the vascular endothelial factor [endothelial vasoconstriction peptide-1(ET-1),nitric oxide(NO)] levels before and after the surgery,and the incidence of complications were compared between the two groups.Results:The success rate of embolization in the early group was 94.12%(48/51),which was higher than 78.72%(37/47) in the control group,and the difference was statistically significant(P<0.05).2 weeks after the surgery,the NIHSS scores of the two groups were lower than those before the surgery,that in the early group was lower than that in the delayed group,and the differences were statistically significant(P<0.05).2 weeks after the surgery,the levels of MDA and D-D in the two groups were lower than those before the surgery,and those in the early group were lower than those in the delayed group;the level of SOD in the two groups was higher than that before the surgery,and that in the early group was higher than that in the delayed group;and the differences were statistically significant(P<0.05).2 weeks after the surgery,the level of ET-1 in both groups was lower than that before the surgery,and that in the early group was lower than that in the delayed grou

关 键 词：血管栓塞术 早期介入 颅内动脉瘤破裂 氧化应激 血管内皮因子 

分 类 号：R743[医药卫生—神经病学与精神病学]