低频重复经颅磁刺激联合枸橼酸坦度螺酮治疗焦虑症患者的效果  

Effects of low frequency repetitive transcranial magnetic stimulation combined with Tandospirone citrate in treatment of patients with anxiety

作　　者：张娟 ZHANG Juan(Department of Psychiatric Disorders of Jian’an Hospital,Xuchang 461000 Henan,China)

机构地区：[1]许昌市建安医院精神病性障碍科,河南许昌461000

出　　处：《中国民康医学》2025年第5期85-88,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察低频重复经颅磁刺激(rTMS)联合枸橼酸坦度螺酮治疗焦虑症患者的效果。方法:选取2022年6月至2023年12月于该院就诊的80例焦虑症患者进行前瞻性研究,根据随机数字表法将其分为对照组和观察组各40例。对照组接受枸橼酸坦度螺酮治疗,观察组在对照组基础上联合低频rTMS治疗,比较两组治疗前后焦虑程度[汉密尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)]评分、睡眠质量[匹兹堡睡眠质量指数量表(PSQI)]评分、神经递质[5-羟色胺(5-HT)、去甲肾上腺素(NE)、γ-氨基丁酸(GABA)]水平、过氧化指标[超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)]水平和不良反应发生率。结果:治疗后,两组HAMA、SAS和PSQI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组5-HT、NE、GABA水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组SOD、GSH-Px水平均高于治疗前,且观察组高于对照组,两组MDA水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:低频rTMS联合枸橼酸坦度螺酮治疗焦虑症患者可提高神经递质水平,改善过氧化指标水平,降低HAMA、SAS和PSQI评分,效果优于单纯枸橼酸坦度螺酮治疗。Objective:To observe effects of low frequency repetitive transcranial magnetic stimulation(rTMS) combined with Tandospirone citrate in treatment of patients with anxiety.Methods:A prospective study was conducted on 80 patients with anxiety who were admitted to the hospital from June 2022 to December 2023.They were divided into control group and observation group by using the random number table method,40 cases in each group.The control group was treated with Tandospirone citrate,while the observation group was treated with lowfrequency rTMS on the basis of that of the control group.The anxiety degree [Hamilton anxiety scale(HAMA),self-rating anxiety scale(SAS)] score,the sleep quality [Pittsburgh sleep quality index(PSQI)] score,the neurotransmitter [5-hydroxytryptamine(5-HT),norepinephrine(NE),γ-aminobutyric acid(GABA)] levels,the peroxide indexes [superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA)] levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the scores of HAMA,SAS and PSQI in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of 5-HT,NE and GABA in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of SOD and GSH-Px in the two groups were higher than those before the treatment,and those in the observation group were higher than those in the control group;the MDA levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between t

关 键 词：焦虑症 低频重复经颅磁刺激 枸橼酸坦度螺酮 神经递质 焦虑程度 睡眠质量 

分 类 号：R749.7[医药卫生—神经病学与精神病学]