藿朴夏苓汤联合四联疗法治疗慢性胃炎湿热中阻证患者的效果  

Effects of Huopu Xialing decoction combined with quadruple therapy in treatment of chronic gastritis patients with dampness-heat obstruction syndrome

作　　者：杜娜 朱辰辰 尚青青 毛海燕 李晓云 张玉琢 杜囚鹏 DU Na;ZHU Chenchen;SHANG Qingqing;MAO Haiyan;LI Xiaoyun;ZHANG Yuzhuo;DU Qiupeng(Department of Gastroenterology,Beijing First Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100018,China)

机构地区：[1]北京市第一中西医结合医院消化内科,北京100018

出　　处：《中国民康医学》2025年第5期118-121,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察藿朴夏苓汤联合四联疗法治疗慢性胃炎湿热中阻证患者的效果。方法:选取2021年6月至2023年3月该院收治的86例慢性胃炎湿热中阻证患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各43例。对照组予以四联疗法治疗,观察组在对照组基础上联合藿朴夏苓汤治疗。比较两组临床疗效,治疗前后中医证候积分、炎性指标[肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)]水平、胃肠激素[胃泌素(GAS)、胃动素(MTL)、生长激素(GH)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.35%(41/43),高于对照组的81.40%(35/43),差异有统计学意义(P<0.05);治疗后,两组胃脘胀满、疼痛间作、食少纳差、口干口臭、口苦泛酸等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组TNF-α、CRP、IL-6、IL-1β水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组GAS水平均低于治疗前,且观察组低于对照组,两组MTL、GH水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:藿朴夏苓汤联合四联疗法治疗慢性胃炎湿热中阻证患者可提高治疗总有效率,降低中医证候积分、炎性指标水平,改善胃肠激素水平,效果优于单纯四联疗法治疗。Objective:To observe effects of Huopu Xialing decoction combined with quadruple therapy in treatment of patients with chronic gastritis with dampness-heat obstruction syndrome.Methods:A prospective study was conducted on 86 patients with chronic gastritis with dampness-heat obstruction syndrome admitted to this hospital from June 2021 to March 2023.According to the random number table method,they were divided into control group and observation group,43 cases in each group.The control group was treated with quadruple therapy,while the observation group was treated with Huopu Xialing decoction on the basis of that of the control group.The clinical efficacy,the Traditional Chinese Medicine(TCM) syndrome score,the inflammatory indexes [tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),interleukin-1β(IL-1β)] levels,the gastrointestinal hormones [gastrin(GAS),motilin(MTL),growth hormone(GH)] levels before and after the treatment,and incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.35%(41/43),which was higher than 81.40%(35/43) of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as epigastric fullness,pain intercropping,poor appetite,dry mouth and halitosis,and bitter taste and acid regurgitation in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of TNF-α,CRP,IL-6 and IL-1β in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the GAS levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the levels of MTL and GH in

关 键 词：慢性胃炎 藿朴夏苓汤 四联疗法 中医证候积分 胃肠激素 炎性因子 不良反应 

分 类 号：R573.32[医药卫生—消化系统]