血清孕酮、雌二醇水平与先兆流产患者保胎结局的相关性分析  

Analysis of correlation between serum progesterone and estradiol levels with tocolysis outcome in patients with threatened abortion

作　　者：黄春霞 HUANG Chunxia(Department of Clinical Laboratory of Xin County Maternal and Child Health Hospital,Xin Yang 465500 Henan,China)

机构地区：[1]新县妇幼保健院检验科,河南信阳465500

出　　处：《中国民康医学》2025年第5期156-158,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析血清孕酮、雌二醇水平与先兆流产患者保胎结局的相关性。方法:回顾性分析2019年1月至2024年3月于该院接受保胎治疗的115例先兆流产产妇的临床资料,根据保胎结局将其分为继续妊娠组(n=91)、妊娠失败组(n=24),另选取同期常规产检的115名产妇,作为对照组。比较三组血清孕酮、雌二醇水平,采用点二列相关分析血清孕酮、雌二醇水平与保胎结局的相关性,并采用限制性立方样条(RCS)分析血清孕酮、雌二醇与保胎结局的剂量反应关系。结果:妊娠失败组、继续妊娠组血清孕酮、雌二醇水平均低于对照组,且妊娠失败组低于继续妊娠组,差异有统计学意义(P<0.05);点二列相关分析结果显示,血清孕酮、雌二醇水平与先兆流产患者妊娠失败均呈负相关(r<0,P<0.05);RCS模型分析结果显示,先兆流产患者保胎结局与血清孕酮、雌二醇水平呈线性剂量反应关系(P<0.05);当孕酮≥12.31 nmol/L,雌二醇≥263.96 pmol/L时,先兆流产患者妊娠失败风险随孕酮、雌二醇水平升高而降低。结论:血清孕酮、雌二醇水平与先兆流产患者妊娠失败均呈负相关,先兆流产患者保胎结局与血清孕酮、雌二醇水平呈线性剂量反应关系,且妊娠失败风险随孕酮、雌二醇水平升高而降低。Objective:To analyze correlation between serum progesterone and estradiol levels and tocolytic outcome in patients with threatened abortion.Methods:The clinical data of 115 cases of threatened abortion treated in this hospital from January 2019 to March 2024 were retrospectively analyzed.According to the tocolytic outcome,they were divided into continued pregnancy group(n=91) and pregnancy failure group(n=24).Another 115 pregnant women who underwent routine prenatal examination during the same period were selected as the control group.The serum progesterone and estradiol levels were compared among the three groups.The correlation between the serum progesterone and estradiol levels and the tocolysis outcome were analyzed by point biserial correlation analysis.The dose-response relationship among the serum progesterone and estradiol levels and the tocolytic outcome was analyzed by restricted cubic spline(RCS).Results:The levels of serum progesterone and estradiol in the pregnancy failure group and the continuous pregnancy group were lower than those in the control group,those in the pregnancy failure group were lower than those in the continuous pregnancy group,and the differences were statistically significant(P<0.05).The point biserial correlation analysis showed that the serum progesterone and estradiol levels were negatively correlated with pregnancy failure in the patients with threatened abortion(r<0,P<0.05).The RCS model analysis showed that there was a linear dose-response relationship among the tocolytic outcome and the levels of serum progesterone and estradiol in the patients with threatened abortion(P<0.05).When progesterone≥12.31 nmol/L and estradiol≥263.96pmol/L,the risk of pregnancy failure in the patients with threatened abortion decreased with the increase of the progesterone and estradiol levels.Conclusions:The serum progesterone and estradiol levels are negatively correlated with pregnancy failure in the patients with threatened abortion.There is a linear dose-response relationship between th

关 键 词：先兆流产 孕酮 雌二醇 妊娠 保胎结局 

分 类 号：R742.5[医药卫生—神经病学与精神病学]