光谱学技术在皮肤恶性肿瘤诊断中的研究进展  

Research progress of spectroscopic techniques in the diagnosis of skin malignant tumors

作　　者：赵舒文 张景展 康晓静[2] Zhao Shuwen;Zhang Jingzhan;Kang Xiaojing(Graduate School of Xinjiang Medical University,Urumqi 830001,China;Dermatology and Venereology Medical Diagnosis and Treatment Center,People′s Hospital of Xinjiang Uygur Autonomous Region,Xinjiang Clinical Research Center for Dermatology and Venereology,Xinjiang Key Laboratory of Dermatology Research,Urumqi 830001,China)

机构地区：[1]新疆医科大学研究生学院,乌鲁木齐830001 [2]新疆维吾尔自治区人民医院皮肤性病医学诊疗中心、新疆皮肤性病临床医学研究中心、新疆皮肤病研究重点实验室,乌鲁木齐830001

出　　处：《中华核医学与分子影像杂志》2025年第2期125-128,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：新疆维吾尔自治区自然科学基金(2022D01D23)。

摘　　要：皮肤恶性肿瘤多发生在光暴露部位。早期诊断并治疗可有效提高患者的生存率。组织病理学检查是临床诊断皮肤恶性肿瘤的"金标准",但该检查是一种侵入性操作,耗时较长且可能出现切口感染、瘢痕形成等风险。近年来,光谱学技术迅速发展,光谱学检测具有非侵入、操作简便、实时检测、高灵敏度等特点,已逐渐应用于皮肤恶性肿瘤的辅助诊断中。该文综述荧光光谱、拉曼光谱、红外光谱等光谱学技术在皮肤恶性肿瘤诊断中的最新研究进展。Skin malignant tumors mostly occur in the light exposure site.Early diagnosis and treatment can effectively improve the survival rate of patients.Histopathological examination is the gold standard for clinical diagnosis of skin malignant tumors,but this method is an invasive operation which brings pain to patients and takes a long time,and may cause problems such as incision infection and scar formation.In recent years,spectroscopy technology has developed rapidly.It is a non-invasive real-time detection method,which can be simply operated,and has a high sensitivity.It has been gradually applied to the diagnosis of skin malignant tumors.This paper reviews the application progress of spectroscopy technology,including fluorescence spectroscopy,Raman spectroscopy and infrared spectroscopy in the diagnosis of skin malignant tumors.

关 键 词：皮肤肿瘤 光谱法 荧光 光谱分析 拉曼 谱学 近红外线 发展趋势 

分 类 号：R739.5[医药卫生—肿瘤]