替普瑞酮联合四联疗法用于Hp阳性胃溃疡患者的疗效研究  

Efficacy study of teprenone combined with quadruple therapy in patients with Hp-positive gastric ulcers

作　　者：相文会 李蓓蓓 魏霞 XIANG Wen-hui;LI Bei-bei;WEI Xia(Department of Gastroenterology,Gaotang County People's Hospital,Liaocheng 252800,China)

机构地区：[1]山东省高唐县人民医院消化内科,252800

出　　处：《中国实用医药》2025年第4期16-20,共5页China Practical Medicine

摘　　要：目的探讨替普瑞酮联合四联疗法治疗幽门螺杆菌(Hp)阳性胃溃疡患者的疗效。方法选取100例Hp阳性胃溃疡患者作为研究对象,通过抛硬币的方式随机分为实验组和对照组,每组50例。对照组采用常规治疗(四联疗法),实验组则在常规治疗的基础上使用替普瑞酮进行治疗。比较两组患者治疗效果,胃黏膜形态学相关指标评分,不良反应发生率,抑郁自评量表(SDS)评分和焦虑自评量表(SAS)评分,生活质量评分。结果实验组治疗总有效率(94.00%)明显高于对照组(80.00%)(P<0.05)。实验组治疗后黏膜厚度、炎性细胞浸润程度、黏膜形态及腺体密度评分分别为(0.44±0.24)、(0.45±0.22)、(0.63±0.24)、(0.96±0.34)分,低于对照组的(0.56±0.25)、(0.58±0.26)、(0.84±0.34)、(1.24±0.64)分(P<0.05)。实验组不良反应发生率(4.00%)低于对照组(22.00%)(P<0.05)。治疗前,两组患者的SDS评分和SAS评分比较没有明显差异(P>0.05);治疗后,实验组患者的SDS评分(42.32±4.30)分和SAS评分(41.43±3.32)分明显低于对照组的(56.36±5.32)、(55.56±3.62)分(P<0.05)。治疗前,两组患者的生理功能、心理功能、情感职能、社会角色评分比较没有明显差异(P>0.05);治疗后,实验组患者的生理功能、心理功能、情感职能、社会角色评分分别为(76.65±2.32)、(74.27±2.69)、(79.21±2.35)、(80.14±2.04)分,均明显高于对照组的(68.18±2.26)、(65.54±2.25)、(68.24±2.01)、(71.01±2.35)分(P<0.05)。结论替普瑞酮联合四联疗法治疗Hp阳性胃溃疡患者在治疗效果、胃黏膜形态学及不良反应控制方面有明显优势,还可以改善患者负面心理,提高患者的生活质量,因此,建议在临床实践中广泛应用此方案。Objective To explore the efficacy of teprenone combined with quadruple therapy in patients with Helicobacter pylori(Hp)-positive gastric ulcers.Methods A total of 100 patients with Hp positive gastric ulcer were selected as the study subjects.They were randomly divided into an experimental group and a control group by the tossing a coin,with 50 cases in each group.The control group received conventional treatment(quadruple therapy),while the experimental group received treatment with teprenone on the basis of conventional treatment.A comparison was conducted on the treatment effect,gastric mucosal morphology related indicators,incidence of adverse reactions,self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)and quality of life score between the two groups of patients.Results The total effective rate of the experimental group(94.00%)was significantly higher than that of the control group(80.00%)(P<0.05).After treatment,the scores of mucosal thickness,inflammatory cell infiltration,mucosal morphology and glandular density in the experimental group were(0.44±0.24),(0.45±0.22),(0.63±0.24)and(0.96±0.34)points,which were lower than(0.56±0.25),(0.58±0.26),(0.84±0.34)and(1.24±0.64)points in the control group(P<0.05).The incidence of adverse reactions in the experimental group(4.00%)was lower than that in the control group(22.00%)(P<0.05).Before treatment,there was no significant difference in SDS score and SAS score between the two groups(P>0.05).After treatment,SDS score and SAS score were(42.32±4.30)and(41.43±3.32)points in the experimental group,which were significantly lower than(56.36±5.32)and(55.56±3.62)points in the control group(P<0.05).Before treatment,there were no significant differences in the scores of physical function,psychological function,role-emotional and social role between the two groups(P>0.05).After treatment,the scores of physical function,psychological function,role-emotional and social role of the experimental group were(76.65±2.32),(74.27±2.69),(79.21±2.35)and(8

关 键 词：幽门螺杆菌阳性胃溃疡 四联疗法 替普瑞酮 疗效 

分 类 号：R47[医药卫生—护理学]