丁苯酞联合替罗非班治疗卒中预警综合征的疗效研究  

Study on the curative effect of butylphthalide combined with tirofiban in the treatment of stroke warning syndrome

作　　者：王硕 WANG Shuo(Department of Neurology,Jining No.1 People's Hospital Sishui Branch Hospital,Jining 273200,China)

机构地区：[1]济宁市第一人民医院泗水院区神经内科,273200

出　　处：《中国实用医药》2025年第4期83-85,共3页China Practical Medicine

摘　　要：目的研究卒中预警综合征患者采用丁苯酞+替罗非班治疗的临床效果。方法107例卒中预警综合征患者,采用投掷硬币法分为参照组(53例)和研究组(54例)。参照组采用丁苯酞治疗,研究组采用丁苯酞+替罗非班治疗。比较两组临床症状发作次数、美国国立卫生研究院卒中量表(NIHSS)评分、NIHSS评分降低情况、进展为脑梗死情况。结果治疗前,两组临床症状发作次数比较差异不明显(P>0.05);治疗后,与参照组的(2.02±0.12)次/d比较,研究组临床症状发作次数(1.02±0.13)次/d明显减少(P<0.05)。治疗前,两组NIHSS评分比较差异不明显(P>0.05);治疗后,与参照组的(4.13±0.25)分比较,研究组NIHSS评分(2.02±0.49)分明显降低(P<0.05)。与参照组的28.30%、18.87%比较,研究组NIHSS评分降低比例59.26%更高,进展为脑梗死比例3.70%更低(P<0.05)。结论临床对卒中预警综合征患者应用丁苯酞+替罗非班联合治疗,可显著减少临床症状发作次数,降低NIHSS评分,同时将NIHSS评分降低比例增加,将进展为脑梗死比例有效减少。Objective To study the clinical effect of butylphthalide combined with tirofiban in the treatment of stroke warning syndrome.Methods 107 patients with stroke warning syndrome were divided into reference group(53 cases)and study group(54 cases)by coin-tossing method.The reference group was treated with butylphthalide,and the study group was treated with butylphthalide+tirofiban.The number of episodes of clinical symptoms,the National Institutes of Health Stroke Scale(NIHSS)score,the NIHSS score reduction and the progression to cerebral infarction were compared between the two groups.Results Before treatment,there was no significant difference in the number of episodes of clinical symptoms between the two groups(P>0.05).After treatment,compared with(2.02±0.12)times/d in the reference group,the number of episodes of clinical symptoms(1.02±0.13)times/d in the study group decreased more significantly(P<0.05).Before treatment,there was no significant difference in NIHSS score between the two groups(P>0.05).After treatment,NIHSS score of(2.02±0.49)points in the study group was significantly decreased compared with(4.13±0.25)points in the reference group(P<0.05).Compared with 28.30%and 18.87%in the reference group,the proportion of NIHSS score reduction(59.26%)was higher and the proportion of progressing to cerebral infarction(3.70%)was lower in the study group(P<0.05).Conclusion Clinical application of butylphthalide plus tirofiban in patients with stroke warning syndrome can significantly reduce the number of episodes of clinical symptoms and NIHSS score,increase the proportion of NIHSS score reduction,and effectively reduce the proportion of progressing to cerebral infarction.

关 键 词：脑血管综合征 丁苯酞 替罗非班 卒中预警综合征 

分 类 号：R743.3[医药卫生—神经病学与精神病学]