替吉奥联合奥沙利铂新辅助化疗治疗胃癌的临床效果  

Clinical effect of tegafur combined with oxaliplatin neoadjuvant chemotherapy in the treatment of gastric cancer

作　　者：毕小伟 BI Xiao-wei(Department of Surgery,Zibo Infectious Disease Hospital,Zibo 255000,China)

机构地区：[1]淄博市传染病医院外科,255000

出　　处：《中国实用医药》2025年第4期110-113,共4页China Practical Medicine

摘　　要：目的分析胃癌患者使用替吉奥联合奥沙利铂新辅助化疗的效果。方法70例胃癌患者,通过随机抽样法分为常规组、研究组,各35例。常规组采用卡培他滨+奥沙利铂新辅助化疗方式治疗,研究组采用替吉奥+奥沙利铂新辅助化疗方式治疗。比较两组疗效,胃癌相关理化指标(癌胚抗原、糖类抗原19-9、糖类抗原125、糖类抗原72-4)水平,血管新生因子(胰岛素样生长因子、内皮生长因子)及免疫功能指标(CD4^(+)、CD8^(+))水平,生活质量,化疗毒副反应发生率。结果研究组有效率为85.71%,高于常规组的57.14%,存在统计学意义(P<0.05)。治疗后,研究组癌胚抗原(3.74±0.66)ng/ml、糖类抗原19-9(28.34±3.03)kU/L、糖类抗原125(23.41±2.15)kU/L、糖类抗原72-4(4.81±0.68)U/ml均低于常规组的(4.87±0.78)ng/ml、(40.64±3.36)kU/L、(35.35±2.87)kU/L、(6.13±1.23)U/ml,存在统计学意义(P<0.05)。治疗后,研究组胰岛素样生长因子(215.23±30.05)μg/ml、内皮生长因子(139.47±17.86)ng/L、CD8^(+)(22.42±2.71)%均低于常规组的(303.65±36.04)μg/ml、(202.83±21.69)ng/L、(25.18±3.58)%,CD4^(+)(39.73±3.79)%高于常规组的(31.07±2.80)%,存在统计学意义(P<0.05)。治疗后,研究组躯体功能、情绪功能、认知功能、社会功能评分分别为(88.78±2.57)、(91.19±2.24)、(90.16±2.38)、(89.88±3.12)分,高于常规组的(80.23±2.02)、(86.16±2.23)、(86.12±1.67)、(84.22±2.05)分,存在统计学意义(P<0.05)。研究组化疗毒副反应发生率为22.86%,低于常规组的51.43%,存在统计学意义(P<0.05)。结论胃癌患者使用替吉奥联合奥沙利铂新辅助化疗方式进行治疗,可以改善患者相关理化指标,能够有效抑制血管新生因子,疗效显著,临床应用价值较高。Objective To analyze the effect of tegafur combined with oxaliplatin neoadjuvant chemotherapy in the treatment of gastric cancer.Methods 70 patients with gastric cancer were randomly divided into conventional group and study group,each with 35 cases.The conventional group was treated with capecitabine+oxaliplatin neoadjuvant chemotherapy,while the study group was treated with tegafur+oxaliplatin neoadjuvant chemotherapy.Comparison was made on therapeutic effects,levels of gastric cancer related physicochemical indicators(carcinoembryonic antigen,carbohydrate antigen 19-9,carbohydrate antigen 125,carbohydrate antigen 72-4),angiogenic factors(insulin-like growth factor,endothelial growth factor)and immune function indicators(CD4^(+),CD8^(+)),quality of life,and incidence of adverse reactions of chemotherapy between the two groups.Results The effective rate of the study group was 85.71%,which was higher than 57.14%of the conventional group,and there was statistical significance(P<0.05).After treatment,the carcinoembryonic antigen,carbohydrate antigen 19-9,carbohydrate antigen 125,and carbohydrate antigen 72-4 were(3.74±0.66)ng/ml,(28.34±3.03)kU/L,(23.41±2.15)kU/L,and(4.81±0.68)U/ml in the study group,which were lower than(4.87±0.78)ng/ml,(40.64±3.36)kU/L,(35.35±2.87)kU/L,and(6.13±1.23)U/ml in the conventional group,and there was statistical significance(P<0.05).After treatment,the insulin-like growth factor,endothelial growth factor and CD8^(+)were(215.23±30.05)μg/ml,(139.47±17.86)ng/L and(22.42±2.71)%in the study group,which were lower than(303.65±36.04)μg/ml,(202.83±21.69)ng/L and(25.18±3.58)%in the conventional group;the study group had higher CD4^(+)of(39.73±3.79)%than(31.07±2.80)%in the conventional group;there was statistical significance(P<0.05).After treatment,the scores of physical function,emotional function,cognitive function and social function were(88.78±2.57),(91.19±2.24),(90.16±2.38)and(89.88±3.12)points in the study group,which were higher than(80.23±2.02),(86.16±2.23),(86.12�

关 键 词：替吉奥 奥沙利铂 新辅助化疗 胃癌 

分 类 号：R73[医药卫生—肿瘤]